Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Norfludiazepam 10-chloro-2-(2-fluorophenyl)- 3,6...

Synonyms: CHEMBL974, AG-E-93459, SureCN5177297, N2144_FLUKA, N2144_SIGMA, ...

Conti, I. et al., Greenblatt, D.J. et al.

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High impact information on CM 7116

In contrast, cimetidine prolonged desalkylflurazepam elimination half-life (141 vs. 94 hours, P less than 0.1) and increased AUC an average of 65 per cent (P less than 0.05) [1].
Propranolol had no significant effects on the kinetics of flutoprazepam or norflutoprazepam, an active metabolite possibly accounting for a substantial part of the parent compound's pharmacological and clinical effects [2].

References

Interaction of cimetidine with oxazepam, lorazepam, and flurazepam. Greenblatt, D.J., Abernethy, D.R., Koepke, H.H., Shader, R.I. Journal of clinical pharmacology. (1984) [Pubmed]
Propranolol does not alter flutoprazepam kinetics and metabolism in the rat. Conti, I., Sarati, S., Caccia, S. European journal of drug metabolism and pharmacokinetics. (1991) [Pubmed]

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