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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Kinetics

 
 
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Disease relevance of Kinetics

 

Psychiatry related information on Kinetics

 

High impact information on Kinetics

  • The Cav3 subtypes can be differentiated by their kinetics and sensitivity to block by Ni2+ [11].
  • Under appropriately controlled conditions of progressive phosphorylation or dephosphorylation, three functionally different phosphoforms of a single CFTR channel can be distinguished on the basis of channel opening and closing kinetics [12].
  • In the CAT family, three genes encode for four different isoforms [CAT-1, CAT-2A, CAT-2(B) and CAT-3]; these are approximately 70-kDa proteins with multiple transmembrane segments (12-14), and despite their structural similarity, they differ in tissue distribution, kinetics, and regulatory properties [13].
  • Kinetics of the multidrug transporter (P-glycoprotein) and its reversal [14].
  • Using this rapid perturbation model, we define the kinetics, dependence, persistence and reversibility of p53-mediated responses to DNA damage in tissues in vivo and to activation of the Ras oncoprotein and stress in vitro [15].
 

Chemical compound and disease context of Kinetics

 

Biological context of Kinetics

 

Anatomical context of Kinetics

 

Associations of Kinetics with chemical compounds

 

Gene context of Kinetics

  • Blockade of TBP-1 expression by small interfering RNA (siRNA) causes prolonged degradation kinetics of Hif1 alpha [34].
  • Moreover, quiescent Cdk4/Cdk6-null cells respond to serum stimulation and enter S phase with normal kinetics although with lower efficiency [35].
  • Experiments examining the kinetics of binding show that Mediator binds to HO promoter elements 1.5 kb upstream of the transcription start site in early G1, but this binding occurs without RNA Pol II [36].
  • In addition, CLN2 transcription is activated with similar kinetics in cells that have CLN2 as their only functional CLN gene and in CLN-deficient cells [37].
  • The initial drop in CLN transcript levels in MMS is not RAD53 dependent, but the kinetics of reaccumulation of CLN messages as cells recover from the damage is faster in rad53-11 cells than in wild type cells [38].
 

Analytical, diagnostic and therapeutic context of Kinetics

References

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