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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Kinetics


Psychiatry related information on Kinetics


High impact information on Kinetics

  • The Cav3 subtypes can be differentiated by their kinetics and sensitivity to block by Ni2+ [11].
  • Under appropriately controlled conditions of progressive phosphorylation or dephosphorylation, three functionally different phosphoforms of a single CFTR channel can be distinguished on the basis of channel opening and closing kinetics [12].
  • In the CAT family, three genes encode for four different isoforms [CAT-1, CAT-2A, CAT-2(B) and CAT-3]; these are approximately 70-kDa proteins with multiple transmembrane segments (12-14), and despite their structural similarity, they differ in tissue distribution, kinetics, and regulatory properties [13].
  • Kinetics of the multidrug transporter (P-glycoprotein) and its reversal [14].
  • Using this rapid perturbation model, we define the kinetics, dependence, persistence and reversibility of p53-mediated responses to DNA damage in tissues in vivo and to activation of the Ras oncoprotein and stress in vitro [15].

Chemical compound and disease context of Kinetics


Biological context of Kinetics


Anatomical context of Kinetics


Associations of Kinetics with chemical compounds


Gene context of Kinetics

  • Blockade of TBP-1 expression by small interfering RNA (siRNA) causes prolonged degradation kinetics of Hif1 alpha [34].
  • Moreover, quiescent Cdk4/Cdk6-null cells respond to serum stimulation and enter S phase with normal kinetics although with lower efficiency [35].
  • Experiments examining the kinetics of binding show that Mediator binds to HO promoter elements 1.5 kb upstream of the transcription start site in early G1, but this binding occurs without RNA Pol II [36].
  • In addition, CLN2 transcription is activated with similar kinetics in cells that have CLN2 as their only functional CLN gene and in CLN-deficient cells [37].
  • The initial drop in CLN transcript levels in MMS is not RAD53 dependent, but the kinetics of reaccumulation of CLN messages as cells recover from the damage is faster in rad53-11 cells than in wild type cells [38].

Analytical, diagnostic and therapeutic context of Kinetics


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  2. Characterization of two different alkaline phosphatases in mouse teratoma: partial purification, electrophoretic, and histochemical studies. Wada, H.G., VandenBerg, S.R., Sussman, H.H., Grove, W.E., Herman, M.M. Cell (1976) [Pubmed]
  3. Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation. Dalemans, W., Barbry, P., Champigny, G., Jallat, S., Dott, K., Dreyer, D., Crystal, R.G., Pavirani, A., Lecocq, J.P., Lazdunski, M. Nature (1991) [Pubmed]
  4. Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Souslova, V., Cesare, P., Ding, Y., Akopian, A.N., Stanfa, L., Suzuki, R., Carpenter, K., Dickenson, A., Boyce, S., Hill, R., Nebenuis-Oosthuizen, D., Smith, A.J., Kidd, E.J., Wood, J.N. Nature (2000) [Pubmed]
  5. Increased cimetidine clearance in burn patients. Martyn, J.A., Greenblatt, D.J., Abernethy, D.R. JAMA (1985) [Pubmed]
  6. Do NMDA receptor kinetics regulate the end of critical periods of plasticity? Medina, A.E., Liao, D.S., Mower, A.F., Ramoa, A.S. Neuron (2001) [Pubmed]
  7. Measurement and modeling of the transient difference between blood and subcutaneous glucose concentrations in the rat after injection of insulin. Schmidtke, D.W., Freeland, A.C., Heller, A., Bonnecaze, R.T. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays. Leissring, M.A., Lu, A., Condron, M.M., Teplow, D.B., Stein, R.L., Farris, W., Selkoe, D.J. J. Biol. Chem. (2003) [Pubmed]
  9. Effect of acute alcohol consumption on lithium kinetics. Anton, R.F., Paladino, J.A., Morton, A., Thomas, R.W. Clin. Pharmacol. Ther. (1985) [Pubmed]
  10. Effect of fluoxetine on psychomotor performance, physiologic response, and kinetics of ethanol. Lemberger, L., Rowe, H., Bergstrom, R.F., Farid, K.Z., Enas, G.G. Clin. Pharmacol. Ther. (1985) [Pubmed]
  11. Molecular physiology of low-voltage-activated t-type calcium channels. Perez-Reyes, E. Physiol. Rev. (2003) [Pubmed]
  12. Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis. Gadsby, D.C., Nairn, A.C. Physiol. Rev. (1999) [Pubmed]
  13. Transporters for cationic amino acids in animal cells: discovery, structure, and function. Devés, R., Boyd, C.A. Physiol. Rev. (1998) [Pubmed]
  14. Kinetics of the multidrug transporter (P-glycoprotein) and its reversal. Stein, W.D. Physiol. Rev. (1997) [Pubmed]
  15. Temporal dissection of p53 function in vitro and in vivo. Christophorou, M.A., Martin-Zanca, D., Soucek, L., Lawlor, E.R., Brown-Swigart, L., Verschuren, E.W., Evan, G.I. Nat. Genet. (2005) [Pubmed]
  16. Influence of continuous physiologic hyperinsulinemia on glucose kinetics and counterregulatory hormones in normal and diabetic humans. Saccà, L., Sherwin, R., Hendler, R., Felig, P. J. Clin. Invest. (1979) [Pubmed]
  17. Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition. Tessari, P., Inchiostro, S., Biolo, G., Trevisan, R., Fantin, G., Marescotti, M.C., Iori, E., Tiengo, A., Crepaldi, G. J. Clin. Invest. (1987) [Pubmed]
  18. Biliary lipids, bile acids, and gallbladder function in the human female. Effects of pregnancy and the ovulatory cycle. Kern, F., Everson, G.T., DeMark, B., McKinley, C., Showalter, R., Erfling, W., Braverman, D.Z., Szczepanik-van Leeuwen, P., Klein, P.D. J. Clin. Invest. (1981) [Pubmed]
  19. Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition. Lu, H.C., Gonzalez, E., Crair, M.C. Neuron (2001) [Pubmed]
  20. Myocardial kinetics of thallium-201 after dipyridamole infusion in normal canine myocardium and in myocardium distal to a stenosis. Okada, R.D., Leppo, J.A., Boucher, C.A., Pohost, G.M. J. Clin. Invest. (1982) [Pubmed]
  21. Genetic control of hematopoietic kinetics revealed by analyses of allophenic mice and stem cell suicide. Van Zant, G., Eldridge, P.W., Behringer, R.R., Dewey, M.J. Cell (1983) [Pubmed]
  22. Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. Pedersen, A.K., FitzGerald, G.A. N. Engl. J. Med. (1984) [Pubmed]
  23. Pharmacokinetics of indomethacin in the neonate. Relation of plasma indomethacin levels to response of the ductus arteriosus. Brash, A.R., Hickey, D.E., Graham, T.P., Stahlman, M.T., Oates, J.A., Cotton, R.B. N. Engl. J. Med. (1981) [Pubmed]
  24. Cell cycle kinetics in human lymphocyte cultures. Morimoto, K., Wolff, S. Nature (1980) [Pubmed]
  25. Unique and repetitive sequences in multiple genes for feather keratin. Kemp, D.J. Nature (1975) [Pubmed]
  26. The regulation of tissue plasminogen activator activity by human fibroblasts. Hoal, E.G., Wilson, E.L., Dowdle, E.B. Cell (1983) [Pubmed]
  27. Acetylcholine receptor degradation measured by density labeling: effects of cholinergic ligands and evidence against recycling. Gardner, J.M., Fambrough, D.M. Cell (1979) [Pubmed]
  28. Effects of pregnancy and contraceptive steroids on gallbladder function. Braverman, D.Z., Johnson, M.L., Kern, F. N. Engl. J. Med. (1980) [Pubmed]
  29. A significant lag in the induction of ovalbumin messenger RNA by steroid hormones: a receptor translocation hypothesis. Palmiter, R.D., Moore, P.B., Mulvihill, E.R. Cell (1976) [Pubmed]
  30. GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier. Seidner, G., Alvarez, M.G., Yeh, J.I., O'Driscoll, K.R., Klepper, J., Stump, T.S., Wang, D., Spinner, N.B., Birnbaum, M.J., De Vivo, D.C. Nat. Genet. (1998) [Pubmed]
  31. Influence of age on secretion of cholesterol and synthesis of bile acids by the liver. Einarsson, K., Nilsell, K., Leijd, B., Angelin, B. N. Engl. J. Med. (1985) [Pubmed]
  32. Kidney kinetics and chloride ion pumps. Kere, J. Nat. Genet. (1999) [Pubmed]
  33. Kinetics of biosynthesis of acetylcholine receptor and subsequent incorporation into plasma membrane of cultured chick skeletal muscle. Devreotes, P.N., Gardner, J.M., Fambrough, D.M. Cell (1977) [Pubmed]
  34. Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Corn, P.G., McDonald, E.R., Herman, J.G., El-Deiry, W.S. Nat. Genet. (2003) [Pubmed]
  35. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Malumbres, M., Sotillo, R., Santamaría, D., Galán, J., Cerezo, A., Ortega, S., Dubus, P., Barbacid, M. Cell (2004) [Pubmed]
  36. The Swi5 activator recruits the Mediator complex to the HO promoter without RNA polymerase II. Bhoite, L.T., Yu, Y., Stillman, D.J. Genes Dev. (2001) [Pubmed]
  37. CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells. Stuart, D., Wittenberg, C. Genes Dev. (1995) [Pubmed]
  38. Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae. Sidorova, J.M., Breeden, L.L. Genes Dev. (1997) [Pubmed]
  39. Mutations in the active site of Escherichia coli phosphofructokinase. Hellinga, H.W., Evans, P.R. Nature (1987) [Pubmed]
  40. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Galy, A., Travis, M., Cen, D., Chen, B. Immunity (1995) [Pubmed]
  41. Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors. Valés-Gómez, M., Reyburn, H.T., Mandelboim, M., Strominger, J.L. Immunity (1998) [Pubmed]
  42. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics. van der Merwe, P.A., Bodian, D.L., Daenke, S., Linsley, P., Davis, S.J. J. Exp. Med. (1997) [Pubmed]
  43. Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleen. Bette, M., Schäfer, M.K., van Rooijen, N., Weihe, E., Fleischer, B. J. Exp. Med. (1993) [Pubmed]
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