Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1LABYR 5-methyl-1-[(2R,5R)-5-[(3- nitro-8-oxo-7,9...

Synonyms: CHEMBL374483

Balzarini, J. et al., Meier, C. et al., Gröschel, B. et al.

Balzarini, Aquaro, Knispel, Rampazzo, Bianchi, Perno, De Clercq, Meier,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on AIDS-045046

The half-life of d4TTP generated intracellularly from d4T- or cycloSal-d4TMP-treated CEM cells was approximately 3.5 h, and the intracellular ratios of d4TTP/d4TMP in cells exposed to cycloSal-d4TMP gradually increased from 1 to 3.4 upon prolonged incubation [1].
The synthesis, hydrolysis, and antiviral evaluation of novel, lipophilic cycloSal-d4TMP derivatives 3a-h of the anti-HIV dideoxynucleoside 2',3'-dideoxy-2',3'-didehydrothymidine (d4T, 1) are reported [2].
Effects of cycloSal-d4TMP derivatives in H9 cells with induced AZT resistance phenotype [3].

Analytical, diagnostic and therapeutic context of AIDS-045046

Radiolabeled cycloSal-d4TMP could be separated as its two R(p) and S(p) diastereomers on high-performance liquid chromatography [1].

References

Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP. Balzarini, J., Aquaro, S., Knispel, T., Rampazzo, C., Bianchi, V., Perno, C.F., De Clercq, E., Meier, C. Mol. Pharmacol. (2000) [Pubmed]
cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system. Meier, C., Lorey, M., De Clercq, E., Balzarini, J. J. Med. Chem. (1998) [Pubmed]
Effects of cycloSal-d4TMP derivatives in H9 cells with induced AZT resistance phenotype. Gröschel, B., Meier, C., Zehner, R., Cinatl, J., Doerr, H.W., Cinatl, J. Nucleosides Nucleotides (1999) [Pubmed]

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