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Chemical Compound Review

CHEBI:34151     (5Z,8Z,10E,14Z)-12-oxoicosa- 5,8,10,14...

Synonyms: HMDB13633, LMFA03060019, FT-0642657, AC1NR1NW, C14807, ...
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Disease relevance of LMFA03060019

  • In previous studies we observed that normal human epidermis forms 12-oxo-eicosatetraenoic acid (12-oxo-ETE) and hepoxilin B3 (HxB3) as major eicosanoids, both being elevated in psoriasis [1].

Analytical, diagnostic and therapeutic context of LMFA03060019

  • The thin layer chromatography analysis of the phospholipid classes after incubation of epidermal cells with [14C]-labeled HxB3, TrXB3, 12-hydroxy-eicosatetraenoic acid (12-HETE), 12-oxo-ETE, or 15-HETE showed that 12-HETE was the most esterified (12-HETE >15-HETE > TrXB3 > 12-oxo-ETE > HxB3) [1].


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