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Disease relevance of Psoriasis


Psychiatry related information on Psoriasis


High impact information on Psoriasis


Chemical compound and disease context of Psoriasis


Biological context of Psoriasis


Anatomical context of Psoriasis

  • Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model [25].
  • This study highlights the critical and proximal role of T cell activation through the B7-CD28/CD152 costimulatory pathway in maintaining the pathology of psoriasis, including the newly recognized accumulation of mature DCs in the epidermis [26].
  • Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a) [27].
  • The membrane-bound IL-15 expression was also significantly lower in the control monocytes of AD patients compared with that in normals and psoriasis patients [28].
  • Noninvolved skin from psoriasis patients was grafted to beige-severe combined immunodeficiency mice, and psoriasis was induced by injection of FasL-positive autologous natural killer cells that were activated by IL-2 [29].

Gene context of Psoriasis

  • In a prospective dose escalation study, we assessed treatment with human IL-4 (rhuIL-4) in 20 patients with severe psoriasis [1].
  • In addition, adult transgenic skin that was still both sensitive to TGF-alpha and subject to mild irritation displayed localized regions of leukocytic infiltration and granular layer loss, characteristics frequently seen in psoriasis in humans [30].
  • Our results reveal that AR exerts activity in the skin that is distinct from that of transgenic transforming growth factor-alpha or other cytokines, and induces skin pathology with striking similarities to psoriasis [31].
  • We investigated the role of the CD28/CD152 pathway in psoriasis in a 26-week, phase I, open-label dose-escalation study [32].
  • By immunohistochemistry, FKN was expressed on ECs in psoriasis, a Th1-dominated skin disorder, but not in Th2-driven atopic dermatitis [33].

Analytical, diagnostic and therapeutic context of Psoriasis


  1. Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease. Ghoreschi, K., Thomas, P., Breit, S., Dugas, M., Mailhammer, R., van Eden, W., van der Zee, R., Biedermann, T., Prinz, J., Mack, M., Mrowietz, U., Christophers, E., Schlöndorff, D., Plewig, G., Sander, C.A., Röcken, M. Nat. Med. (2003) [Pubmed]
  2. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Homey, B., Alenius, H., Müller, A., Soto, H., Bowman, E.P., Yuan, W., McEvoy, L., Lauerma, A.I., Assmann, T., Bünemann, E., Lehto, M., Wolff, H., Yen, D., Marxhausen, H., To, W., Sedgwick, J., Ruzicka, T., Lehmann, P., Zlotnik, A. Nat. Med. (2002) [Pubmed]
  3. Interleukin-10 therapy--review of a new approach. Asadullah, K., Sterry, W., Volk, H.D. Pharmacol. Rev. (2003) [Pubmed]
  4. Clinical applications of fish oils. Yetiv, J.Z. JAMA (1988) [Pubmed]
  5. Pancytopenia following low-dose oral methotrexate therapy for psoriasis. Shupack, J.L., Webster, G.F. JAMA (1988) [Pubmed]
  6. The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial. Allan, S.J., Kavanagh, G.M., Herd, R.M., Savin, J.A. Br. J. Dermatol. (2004) [Pubmed]
  7. Alcohol intake and treatment responsiveness of psoriasis: a prospective study. Gupta, M.A., Schork, N.J., Gupta, A.K., Ellis, C.N. J. Am. Acad. Dermatol. (1993) [Pubmed]
  8. Massage therapy for infants and children. Field, T. Journal of developmental and behavioral pediatrics : JDBP. (1995) [Pubmed]
  9. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Helms, C., Cao, L., Krueger, J.G., Wijsman, E.M., Chamian, F., Gordon, D., Heffernan, M., Daw, J.A., Robarge, J., Ott, J., Kwok, P.Y., Menter, A., Bowcock, A.M. Nat. Genet. (2003) [Pubmed]
  10. Fludarabine and psoriasis. Smith, O.P., Hoffbrand, A.V., Buckley, C. N. Engl. J. Med. (1994) [Pubmed]
  11. Exacerbation of psoriasis with meclofenamate. Meyerhoff, J.O. N. Engl. J. Med. (1983) [Pubmed]
  12. Inflammatory bowel disease, psoriasis, and complement. Rosenberg, E.W., Spitzer, R.E., Marley, W.M., Belew, P.W. N. Engl. J. Med. (1982) [Pubmed]
  13. Cyclosporin A for psoriasis. Mueller, W., Herrmann, B. N. Engl. J. Med. (1979) [Pubmed]
  14. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Dixon, R.A., Diehl, R.E., Opas, E., Rands, E., Vickers, P.J., Evans, J.F., Gillard, J.W., Miller, D.K. Nature (1990) [Pubmed]
  15. Tyrosine kinase inhibition: an approach to drug development. Levitzki, A., Gazit, A. Science (1995) [Pubmed]
  16. Dermatology. Dover, J.S., Arndt, K.A. JAMA (1995) [Pubmed]
  17. Is methotrexate therapy for psoriasis carcinogenic? A modified retrospective-prospective analysis. Bailin, P.L., Tindall, J.P., Roenigk, H.H., Hogan, M.D. JAMA (1975) [Pubmed]
  18. Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis. Guttman-Yassky, E., Lowes, M.A., Fuentes-Duculan, J., Whynot, J., Novitskaya, I., Cardinale, I., Haider, A., Khatcherian, A., Carucci, J.A., Bergman, R., Krueger, J.G. J. Allergy Clin. Immunol. (2007) [Pubmed]
  19. Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Conrad, C., Boyman, O., Tonel, G., Tun-Kyi, A., Laggner, U., de Fougerolles, A., Kotelianski, V., Gardner, H., Nestle, F.O. Nat. Med. (2007) [Pubmed]
  20. A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis. Haase, I., Hobbs, R.M., Romero, M.R., Broad, S., Watt, F.M. J. Clin. Invest. (2001) [Pubmed]
  21. Evidence for posttranscriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis. Tyner, A.L., Fuchs, E. J. Cell Biol. (1986) [Pubmed]
  22. Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides. Wraight, C.J., White, P.J., McKean, S.C., Fogarty, R.D., Venables, D.J., Liepe, I.J., Edmondson, S.R., Werther, G.A. Nat. Biotechnol. (2000) [Pubmed]
  23. Sequence and Haplotype Analysis Supports HLA-C as the Psoriasis Susceptibility 1 Gene. Nair, R.P., Stuart, P.E., Nistor, I., Hiremagalore, R., Chia, N.V., Jenisch, S., Weichenthal, M., Abecasis, G.R., Lim, H.W., Christophers, E., Voorhees, J.J., Elder, J.T. Am. J. Hum. Genet. (2006) [Pubmed]
  24. Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus. Asumalahti, K., Veal, C., Laitinen, T., Suomela, S., Allen, M., Elomaa, O., Moser, M., de Cid, R., Ripatti, S., Vorechovsky, I., Marcusson, J.A., Nakagawa, H., Lazaro, C., Estivill, X., Capon, F., Novelli, G., Saarialho-Kere, U., Barker, J., Trembath, R., Kere, J. Hum. Mol. Genet. (2002) [Pubmed]
  25. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Sano, S., Chan, K.S., Carbajal, S., Clifford, J., Peavey, M., Kiguchi, K., Itami, S., Nickoloff, B.J., DiGiovanni, J. Nat. Med. (2005) [Pubmed]
  26. Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells. Abrams, J.R., Kelley, S.L., Hayes, E., Kikuchi, T., Brown, M.J., Kang, S., Lebwohl, M.G., Guzzo, C.A., Jegasothy, B.V., Linsley, P.S., Krueger, J.G. J. Exp. Med. (2000) [Pubmed]
  27. Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Lowes, M.A., Chamian, F., Abello, M.V., Fuentes-Duculan, J., Lin, S.L., Nussbaum, R., Novitskaya, I., Carbonaro, H., Cardinale, I., Kikuchi, T., Gilleaudeau, P., Sullivan-Whalen, M., Wittkowski, K.M., Papp, K., Garovoy, M., Dummer, W., Steinman, R.M., Krueger, J.G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  28. Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis. Ong, P.Y., Hamid, Q.A., Travers, J.B., Strickland, I., Al Kerithy, M., Boguniewicz, M., Leung, D.Y. J. Immunol. (2002) [Pubmed]
  29. Fas pulls the trigger on psoriasis. Gilhar, A., Yaniv, R., Assy, B., Serafimovich, S., Ullmann, Y., Kalish, R.S. Am. J. Pathol. (2006) [Pubmed]
  30. Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Vassar, R., Fuchs, E. Genes Dev. (1991) [Pubmed]
  31. Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. Cook, P.W., Piepkorn, M., Clegg, C.H., Plowman, G.D., DeMay, J.M., Brown, J.R., Pittelkow, M.R. J. Clin. Invest. (1997) [Pubmed]
  32. CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. Abrams, J.R., Lebwohl, M.G., Guzzo, C.A., Jegasothy, B.V., Goldfarb, M.T., Goffe, B.S., Menter, A., Lowe, N.J., Krueger, G., Brown, M.J., Weiner, R.S., Birkhofer, M.J., Warner, G.L., Berry, K.K., Linsley, P.S., Krueger, J.G., Ochs, H.D., Kelley, S.L., Kang, S. J. Clin. Invest. (1999) [Pubmed]
  33. Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses. Fraticelli, P., Sironi, M., Bianchi, G., D'Ambrosio, D., Albanesi, C., Stoppacciaro, A., Chieppa, M., Allavena, P., Ruco, L., Girolomoni, G., Sinigaglia, F., Vecchi, A., Mantovani, A. J. Clin. Invest. (2001) [Pubmed]
  34. PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis: a possible cellular basis for remittive therapy. Vallat, V.P., Gilleaudeau, P., Battat, L., Wolfe, J., Nabeya, R., Heftler, N., Hodak, E., Gottlieb, A.B., Krueger, J.G. J. Exp. Med. (1994) [Pubmed]
  35. Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. Nestle, F.O., Conrad, C., Tun-Kyi, A., Homey, B., Gombert, M., Boyman, O., Burg, G., Liu, Y.J., Gilliet, M. J. Exp. Med. (2005) [Pubmed]
  36. Combination phototherapy of psoriasis with calcipotriol and narrow-band UVB. Kerscher, M., Volkenandt, M., Plewig, G., Lehmann, P. Lancet (1993) [Pubmed]
  37. Intralesional injection of cyclosporin in psoriasis. Powles, A.V., Baker, B.S., McFadden, J., Rutman, A.J., Griffiths, C.E., Fry, L., Valdimarsson, H. Lancet (1988) [Pubmed]
  38. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Grossman, R.M., Krueger, J., Yourish, D., Granelli-Piperno, A., Murphy, D.P., May, L.T., Kupper, T.S., Sehgal, P.B., Gottlieb, A.B. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
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