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Chemical Compound Review:

Narcanti

Synonyms: Naloxona, naloxone, Nalossone, Naloxonum, Nalone, ...

Shoblock, J.R. et al., Lunzer, M.M. et al.

James R. Shoblock, Nigel T. Maidment,

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Disease relevance of naloxone

The present study suggests that naloxone may be clinically useful in the treatment of pain associated with sickle cell disease and other disorders involving inflammation [1].

Associations of naloxone with other chemical compounds

These data suggest that morphine may enhance naloxone CPA by increasing levels of constitutively active mu receptors and further support the role of such constitutive activity in mediating naloxone-precipitated physical withdrawal [2].

References

Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia. Lunzer, M.M., Yekkirala, A., Hebbel, R.P., Portoghese, P.S. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
Constitutively active micro opioid receptors mediate the enhanced conditioned aversive effect of naloxone in morphine-dependent mice. Shoblock, J.R., Maidment, N.T. Neuropsychopharmacology (2006) [Pubmed]

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