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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

morphine    

Synonyms: Epimorph, Meconium, Morphina, Morphia, Oramorph SR, ...
 
 
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Associations of morphine with other chemical compounds

  • DeltaFosB overexpression in the NAc increased the sensitivity of the mice to the rewarding effects of morphine and led to exacerbated physical dependence, but also reduced their sensitivity to the analgesic effects of morphine and led to faster development of analgesic tolerance [1].
  • We show that the ability of morphine withdrawal to stimulate phosphorylation at this seryl residue is reduced by SL327, an inhibitor of ERK(1/2) activation [2].
  • Receptor binding studies and FRET measurements demonstrated that several (R)-configurated morphine precursors such as (R)-reticuline, salutaridine, salutaridinol, thebaine, and codeine were partial MOR agonists [3].
  • Antinociception induced by s.c., intrathecal, or intracerebroventricular injection of the morphine metabolite morphine-6-glucuronide (M-6-G) was significantly decreased by sciatic nerve ligation [4].
 

Gene context of morphine

References

  1. An essential role for DeltaFosB in the nucleus accumbens in morphine action. Zachariou, V., Bolanos, C.A., Selley, D.E., Theobald, D., Cassidy, M.P., Kelz, M.B., Shaw-Lutchman, T., Berton, O., Sim-Selley, L.J., Dileone, R.J., Kumar, A., Nestler, E.J. Nat. Neurosci. (2006) [Pubmed]
  2. Regulation of serine (Ser)-31 and Ser40 tyrosine hydroxylase phosphorylation during morphine withdrawal in the hypothalamic paraventricular nucleus and nucleus tractus solitarius-A2 cell group: role of ERK1/2. Núñez, C., Laorden, M.L., Milanés, M.V. Endocrinology (2007) [Pubmed]
  3. Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors. Nikolaev, V.O., Boettcher, C., Dees, C., Bünemann, M., Lohse, M.J., Zenk, M.H. J. Biol. Chem. (2007) [Pubmed]
  4. Comparative pharmacological profiles of morphine and oxycodone under a neuropathic pain-like state in mice: evidence for less sensitivity to morphine. Narita, M., Nakamura, A., Ozaki, M., Imai, S., Miyoshi, K., Suzuki, M., Suzuki, T. Neuropsychopharmacology (2008) [Pubmed]
  5. Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence. Kim, J.A., Bartlett, S., He, L., Nielsen, C.K., Chang, A.M., Kharazia, V., Waldhoer, M., Ou, C.J., Taylor, S., Ferwerda, M., Cado, D., Whistler, J.L. Curr. Biol. (2008) [Pubmed]
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