Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Rapamune

Synonyms: Perceiva, Sirolimus, rapamycin, sirolimusum, RAPA, ...

Cohen, E.E. et al.

Ezra E. W. Cohen, Kehua Wu, Christine Hartford, Masha Kocherginsky, Kimberly Napoli Eaton, Yuanyuan Zha, Anitha Nallari, Michael L. Maitland, Kammi Fox-Kay, Kristin Moshier, Larry House, Jacqueline Ramirez, Samir D. Undevia, Gini F. Fleming, Thomas F. Gajewski, Mark J. Ratain,

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Associations of Rapamune with other chemical compounds

The target sirolimus area under the concentration curve (AUC) of 3,810 ng-h/mL was achieved at sirolimus doses of 90, 16, and 25 mg in the sirolimus alone, sirolimus plus ketoconazole, and sirolimus plus grapefruit juice studies, respectively [1].

References

Phase I studies of sirolimus alone or in combination with pharmacokinetic modulators in advanced cancer patients. Cohen, E.E., Wu, K., Hartford, C., Kocherginsky, M., Eaton, K.N., Zha, Y., Nallari, A., Maitland, M.L., Fox-Kay, K., Moshier, K., House, L., Ramirez, J., Undevia, S.D., Fleming, G.F., Gajewski, T.F., Ratain, M.J. Clin. Cancer Res. (2012) [Pubmed]

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