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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Etacstil     (E)-3-[4-[(Z)-1,2- diphenylbut-1...

Synonyms: CHEMBL33899, AC1NRBM8, SureCN667262, CHEBI:152511, BIDD:ER0054, ...
 
 
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High impact information on GW 5638

  • CONCLUSIONS: Despite similar binding affinities to isolated ERalpha and ERbeta, GW-5638 and GW-7604 show markedly lower EC(50) values with ERbeta at an AP-1-driven promoter as compared to ERalpha [1].
  • We examined in vivo effects of selective estrogen receptor modulators (SERMs) 4-OH-tamoxifen (Tam), GW 5638 (GW) and EM-800 (EM) on myometrial gene expression [2].

References

  1. Differential SERM activation of the estrogen receptors (ERalpha and ERbeta) at AP-1 sites. Weatherman, R.V., Clegg, N.J., Scanlan, T.S. Chem. Biol. (2001) [Pubmed]
  2. Myometrial effects of selective estrogen receptor modulators on estradiol-responsive gene expression are gene and cell-specific. Farnell, Y.Z., Ing, N.H. J. Steroid Biochem. Mol. Biol. (2003) [Pubmed]
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