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Chemical Compound Review:

AC1NSKE2 2-benzofuran-2-yl-4- isothiocyanato-4,5...

Synonyms: 5-Isothiocyanato-2-Benzofuranyl-2-Imidazoline

Tyacke, R.J. et al., Garcia-Sevilla, J.A. et al., Paterson, L.M. et al.

Garcia-Sevilla, Ferrer-Alcon,

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High impact information on 5-Isothiocyanato-2-Benzofuranyl-2-Imidazoline

In vitro and in vivo effect of BU99006 (5-isothiocyanato-2-benzofuranyl-2-imidazoline) on I(2) binding in relation to MAO: Evidence for two distinct I(2) binding sites [1].
In this study, the in vivo effects of the selective I(2)-alkylating agent BU99006 (5-isothiocyanato-2-benzofuranyl-2-imidazoline) on immunoreactive IR proteins were assessed in the mouse brain to unravel the molecular nature of the I(2)R subtypes [2].

Biological context of 5-Isothiocyanato-2-Benzofuranyl-2-Imidazoline

5-Isothiocyanato-2-benzofuranyl-2-imidazoline (BU99006) is an irreversible ligand based on the highly selective I(2) binding site ligand 2BFI [3].

References

In vitro and in vivo effect of BU99006 (5-isothiocyanato-2-benzofuranyl-2-imidazoline) on I(2) binding in relation to MAO: Evidence for two distinct I(2) binding sites. Paterson, L.M., Tyacke, R.J., Robinson, E.S., Nutt, D.J., Hudson, A.L. Neuropharmacology (2007) [Pubmed]
In vivo effects of the I(2)-alkylating agent BU99006 on the immunodensity of imidazoline receptor proteins in the mouse brain. Garcia-Sevilla, J.A., Ferrer-Alcon, M. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
5-Isothiocyanato-2-benzofuranyl-2-imidazoline (BU99006) an irreversible imidazoline(2) binding site ligand: in vitro and in vivo characterisation in rat brain. Tyacke, R.J., Robinson, E.S., Nutt, D.J., Hudson, A.L. Neuropharmacology (2002) [Pubmed]

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