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Chemical Compound Review

AC1NSKQL     (Z)-7-[(2S,3R,5R)-5-chloro-2- [(E,3S)-3...

Synonyms: ZK110841
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High impact information on ZK110841

  • The rank order of compound affinities at the DP receptor was SQ27986 (K(i) = 10 +/- 2 nM) > RS93520 = ZK110841 = BW245C (K(i) = 23-26 nM) > ZK118182 (K(i) = 50 +/- 9 nM) > PGD(2) (K(i) = 80 +/- 5 nM) [1].
  • The half-maximally effective concentration of PGD2 or ZK110841 was 10-30 nM [2].

Associations of ZK110841 with other chemical compounds

  • All compounds were antagonized by the selective DP receptor antagonist BW A868C (3-benzyl-5-(6-carboxyhexyl)-1-(2-cyclohexyl-2-hydroxyethylamino)h ydantoin), but the pKB values were both concentration-dependent (pKB versus BW 245C at 10 nM = 9.1, at 50 nM = 8.3) and agonist-dependent (pKB at 10 nM versus BW 245C = 9.1, versus ZK110841 = 7.4) [3].


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