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Chemical Compound Review

CHEMBL2107464     7-[2-hydroxy-3-[4-(3- phenylsulfanylpropyl)...

Synonyms: SureCN10568172, AC1L1GZI, AC1Q3ESK, RS-49014, LS-126896, ...
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High impact information on TAZIFYLLINE

  • Single oral doses (5, 10 and 15 mg) of the new H1-receptor antagonist 3,7-dihydro-7-[2-hydroxy-3-[4-[3-phenylthio) propyl]-1-piperazinyl]propyl-1,3-dimethyl-1H-purine-2,6-dione dihydrochloride (tazifylline, RS-49014) were administered at 7-day intervals to 12 atopic and 12 non-atopic volunteers in a double-blind randomised cross-over study [1].


  1. Antiallergic effects of the new histamine H1-receptor antagonist tazifylline in healthy atopic and non-atopic subjects. Ring, J., Galosi, A., Harlow, B.J., Reuter, C.A., Bieber, T., Ruzicka, T., Yee, K.F. Arzneimittel-Forschung. (1988) [Pubmed]
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