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Chemical Compound Review

LS-7717     2,4,5,6-tetrafluorobenzene- 1,3-diamine...

Synonyms: AC1L3Y9Z, 63886-77-1, Tetrafluoro-m-phenylenediamine.2HCl
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Disease relevance of NSC 114705


Psychiatry related information on NSC 114705

  • The role of host defense mechanisms in preventing the development of subclinical tumors into invasive tumors in an autochithonous host was studied in a model of rat colon carcinoma induced by 1,2-dimethylhydrazine dihydrochloride (DMH) [5].
  • Rats exposed to learned helplessness (LH), an animal model of depression, showed a recovery following an intracerebroventricular injection of nor-binaltorphimine dihydrochloride (norBNI; a kappa-opioid antagonist) [6].
  • Among them, 2-(4-methyl-1-piperazinyl)-3-(4-fluorophenyl)-5H-1-benzazepine dihydrochloride (23) was comparable to chlorpromazine in inhibiting exploratory activity, conditioned avoidance response, and self-stimulation response and more potent than chlorpromazine in antagonizing apomorphine-induced emesis [7].
  • The selective sigma1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenyl propyl)piperazine dihydrochloride (SA4503) was reported to reverse the amnesia induced by the muscarinic receptor antagonist scopolamine at sub-mg/kg doses [8].

High impact information on NSC 114705


Chemical compound and disease context of NSC 114705


Biological context of NSC 114705


Anatomical context of NSC 114705


Associations of NSC 114705 with other chemical compounds


Gene context of NSC 114705


Analytical, diagnostic and therapeutic context of NSC 114705


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