Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NUKHG [[(2R)-1-(6-aminopurin-9- yl)propan-2...

Synonyms: CHEMBL1538, PMPA prodrug, cc-668, CHEBI:63717, DAP001430, ...

Robbins, B.L. et al.

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High impact information on PMPA prodrug

The anti-human immunodeficiency virus activity of bis(POC)PMPA was >100-fold greater than that of PMPA in both an established T-cell line and primary peripheral blood lymphocytes [1].
The half-life for the disappearance of PMPApp, derived from either bis(POC)PMPA or PMPA, was 12 to 15 h in the activated lymphocytes and 33 to 50 h in the resting lymphocytes [1].

Associations of PMPA prodrug with other chemical compounds

PMPApp levels in bis(POC)PMPA-treated cells exceeded by >1,000-fold the levels seen in cells treated with unmodified PMPA in both resting and activated peripheral blood lymphocytes [1].

References

Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA. Robbins, B.L., Srinivas, R.V., Kim, C., Bischofberger, N., Fridland, A. Antimicrob. Agents Chemother. (1998) [Pubmed]

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