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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Lymphocytes


Psychiatry related information on Lymphocytes


High impact information on Lymphocytes


Chemical compound and disease context of Lymphocytes


Biological context of Lymphocytes


Anatomical context of Lymphocytes


Associations of Lymphocytes with chemical compounds


Gene context of Lymphocytes

  • A hypothetical major role of CSF-1-independent M phi is to collaborate with lymphocytes in mounting an immune response [33].
  • Lymphocyte interactions with high endothelial venules (HEV) during extravasation into lymphoid tissues involve an 85-95 kd class of lymphocyte surface glycoprotein(s), gp90Hermes (CD44) [34].
  • Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes [35].
  • PMN, but not lymphocyte, LECAM-1 is modified with the vascular selectin ligand sialyl Lewis x (sLex) and specifically binds ELAM-1-transfected cells [36].
  • Wnt signaling stabilizes beta-catenin, which accumulates in the cytoplasm, binds to 1-cell factor (TCF; also known as lymphocyte enhancer-binding factor, LEF) and then upregulates downstream genes [37].

Analytical, diagnostic and therapeutic context of Lymphocytes

  • We conclude that the lymphocytes of patients with AIDS, although capable of undergoing a normal degree of blast transformation and lymphokine production after mitogenic stimulation, have an intrinsic defect in their ability to recognize and respond to soluble antigen [38].
  • Cell-mediated responses in patients with acute and chronic forms of Type B hepatitis were tested by lymphocyte transformation to purified hepatitis surface antigen (HBS Ag) and to phytohemagglutinin, by dinitrochlorobenzene sensitization and by response to skin-test antigens [39].
  • To identify dominant (clonal) rearrangements of the T-cell receptor within the lymphocyte population, Southern blot analysis (beta chain) and the polymerase chain reaction (gamma chain) were performed according to standard protocols [40].
  • Using this method, we studied CMV-specific CD4+ lymphocyte responses in individuals infected with HIV-1 with and without a history of active CMV-associated end organ disease (EOD), and in those with quiescent CMV EOD after ganciclovir therapy and HAART [41].
  • To test a potential anti-HIV gene therapy strategy in this model, CD4-enriched lymphocytes from three rhesus macaques were subjected to retrovirally mediated gene transfer with a vector expressing an antisense tat/rev gene [42].


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  15. Prostaglandin-producing suppressor cells in Hodgkin's disease. Goodwin, J.S., Messner, R.P., Bankhurst, A.D., Peake, G.T., Saiki, J.H., Williams, R.C. N. Engl. J. Med. (1977) [Pubmed]
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  22. Further evidence that "malignant angioendotheliomatosis" is an angiotropic large-cell lymphoma. Sheibani, K., Battifora, H., Winberg, C.D., Burke, J.S., Ben-Ezra, J., Ellinger, G.M., Quigley, N.J., Fernandez, B.B., Morrow, D., Rappaport, H. N. Engl. J. Med. (1986) [Pubmed]
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  34. A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins. Goldstein, L.A., Zhou, D.F., Picker, L.J., Minty, C.N., Bargatze, R.F., Ding, J.F., Butcher, E.C. Cell (1989) [Pubmed]
  35. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Osborn, L., Hession, C., Tizard, R., Vassallo, C., Luhowskyj, S., Chi-Rosso, G., Lobb, R. Cell (1989) [Pubmed]
  36. The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Picker, L.J., Warnock, R.A., Burns, A.R., Doerschuk, C.M., Berg, E.L., Butcher, E.C. Cell (1991) [Pubmed]
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