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Chemical Compound Review:

Mammein 5,7-dihydroxy-8-(3- methylbutanoyl)-6-(3...

Synonyms: Mammea B/BA, AC1NURA0, CHEMBL1689183, CHEBI:69988, CTK8I9987, ...

Ouahouo, B.M. et al., Yang, H. et al., Yang, H. et al., Reyes-Chilpa, R. et al.

Reyes-Chilpa, Estrada-Muñiz, Apan, Amekraz, Aumelas, Jankowski, Vázquez-Torres,

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High impact information on Mammein

Antioxidant-guided fractionation of Mammea americana L. seeds resulted in the identification of three new isoprenylated coumarins, mammea B/BA hydroxycyclo F (1), mammea E/BC (2), and mammea E/BD (3) [1].
Ten major mammea coumarins, mammea E/BD (1), mammea E/BC (2), mammea E/BA (3), mammea E/BB (4), mammea B/BA hydroxycyclo F (5), mammea B/BD (6), mammea B/BC (7), mammea B/BA (8), mammea B/BB (9), and mammea B/BA cyclo F (10), were isolated and identified from the seed nucleus of M. americana and employed as standards [2].
Six coumarin derivatives [three 4-phenylcoumarins (Mammea A/AA, Mammea A/BA and MAB 3), two 4-n-propylcoumarins (Mammea B/BB and Mammea B/BA) and one 4-n-pentylcoumarin (Mammea C/OB)], 1,5-dihydroxyxanthone and 1-methoxy-5-hydroxyxanthone have been isolated from the stem bark of Mammea africana Sabine collected in Cameroon [3].
The mixtures of mammea A/BA + A/BB, mammea B/BA + B/BB and mammea C/OA + C/OB were also highly active (IC50 < 4.05 microM) [4].

References

Antioxidant and cytotoxic isoprenylated coumarins from Mammea americana. Yang, H., Protiva, P., Gil, R.R., Jiang, B., Baggett, S., Basile, M.J., Reynertson, K.A., Weinstein, I.B., Kennelly, E.J. Planta Med. (2005) [Pubmed]
Comparative analyses of bioactive Mammea coumarins from seven parts of Mammea americana by HPLC-PDA with LC-MS. Yang, H., Jiang, B., Reynertson, K.A., Basile, M.J., Kennelly, E.J. J. Agric. Food Chem. (2006) [Pubmed]
Cytotoxic and antimicrobial coumarins from Mammea africana. Ouahouo, B.M., Azebaze, A.G., Meyer, M., Bodo, B., Fomum, Z.T., Nkengfack, A.E. Ann. Trop. Med. Parasitol. (2004) [Pubmed]
Cytotoxic effects of mammea type coumarins from Calophyllum brasiliense. Reyes-Chilpa, R., Estrada-Muñiz, E., Apan, T.R., Amekraz, B., Aumelas, A., Jankowski, C.K., Vázquez-Torres, M. Life Sci. (2004) [Pubmed]

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