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Chemical Compound Review:

CHEMBL39338 (2S,4S)-2-amino-4-(4,4...

Synonyms: SureCN4257120, CHEBI:158112, PDSP1_000257, PDSP2_000256, LY-307,452, ...

Schoepp, D.D. et al., Sung, K.W. et al., Dutar, P. et al.

Schoepp, Johnson, Wright, Salhoff, Mayne, Wu, Cockerman, Burnett, Belegaje, Bleakman, Monn,

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High impact information on LY307452

The group II mGluR antagonist LY307452 (10 microM) did not block LTD induction at corticostriatal synapses, but LY307452 was able to block transient synaptic depression induced by the group II agonist LY314593 [1].
The group II mGluR antagonist LY307452 fully antagonized the ACPD response and reduced the response induced by L-CCG-I [2].
LY354740 inhibition of forskolin-stimulated cAMP formation in human mGlu2 receptor-expressing cells was blocked by competitive mGlu receptor antagonists, including (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) and LY307452 ((2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid) [3].

References

Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses. Sung, K.W., Choi, S., Lovinger, D.M. J. Neurophysiol. (2001) [Pubmed]
Pharmacological characterization of an unusual mGluR-evoked neuronal hyperpolarization mediated by activation of GIRK channels. Dutar, P., Vu, H.M., Perkel, D.J. Neuropharmacology (1999) [Pubmed]
LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Schoepp, D.D., Johnson, B.G., Wright, R.A., Salhoff, C.R., Mayne, N.G., Wu, S., Cockerman, S.L., Burnett, J.P., Belegaje, R., Bleakman, D., Monn, J.A. Neuropharmacology (1997) [Pubmed]

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