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Chemical Compound Review

AC1O44IM     4-[(2Z)-2-[4-methanoyl-6- methyl-5-oxo-3...

Synonyms:
 
 
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High impact information on MRS2159

  • SIPA-induced MLC phosphorylation occurred exclusively through released nucleotides and selective antagonism of P2X(1) with MRS2159-reduced SIPA, ATP release, and potently inhibited MLC phosphorylation [1].
  • In human platelets, aggregation to low/threshold stimulation of PAR1 was inhibited with the P2X1 antagonist MRS2159 [2].

References

  1. ATP augments von Willebrand factor-dependent shear-induced platelet aggregation through Ca2+-calmodulin and myosin light chain kinase activation. Oury, C., Sticker, E., Cornelissen, H., De Vos, R., Vermylen, J., Hoylaerts, M.F. J. Biol. Chem. (2004) [Pubmed]
  2. P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation. Erhardt, J.A., Toomey, J.R., Douglas, S.A., Johns, D.G. J. Thromb. Haemost. (2006) [Pubmed]
 
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