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Chemical Compound Review:

SureCN5967399 2-amino-3-naphthalen-1-yl- propanoic acid...

Synonyms: ACMC-209amd, ACMC-209ame, NSC-20166, AC1O4DQJ, NSC20166, ...

This record was replaced with 99505.

Marquis, R.W. et al., De Filippis, V. et al., Amartey, J.K. et al.

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High impact information on NSC20166

Optimization of cathepsin L binding by the combination of the P3 naphthylene-1-carboxamide with the P2 beta-naphthylalanine provided 15, which is a potent, selective, and competitive inhibitor of human cathepsin L with a K(i) = 0.43 nM [1].
In this view, we have synthesized an analogue of fragment 1-47 of hirudin HM2 in which Val1 has been replaced by tert-butylglycine, Ser2 by Arg, and Tyr3 by beta-naphthylalanine, to give the BugArgNal analogue [2].
Synthesis and evaluation of radioiodinated substituted beta-naphthylalanine as a potential probe for pancreatic beta-cells imaging [3].

References

Azepanone-based inhibitors of human cathepsin L. Marquis, R.W., James, I., Zeng, J., Trout, R.E., Thompson, S., Rahman, A., Yamashita, D.S., Xie, R., Ru, Y., Gress, C.J., Blake, S., Lark, M.A., Hwang, S.M., Tomaszek, T., Offen, P., Head, M.S., Cummings, M.D., Veber, D.F. J. Med. Chem. (2005) [Pubmed]
Incorporation of noncoded amino acids into the N-terminal domain 1-47 of hirudin yields a highly potent and selective thrombin inhibitor. De Filippis, V., Russo, I., Vindigni, A., Di Cera, E., Salmaso, S., Fontana, A. Protein Sci. (1999) [Pubmed]
Synthesis and evaluation of radioiodinated substituted beta-naphthylalanine as a potential probe for pancreatic beta-cells imaging. Amartey, J.K., Esguerra, C., Al-Jammaz, I., Parhar, R.S., Al-Otaibi, B. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (2006) [Pubmed]

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