MeSH Review:
Insulin-Secreting Cells
Rohrer,
Birzin,
Mosley,
Berk,
Hutchins,
Shen,
Xiong,
Hayes,
Parmar,
Foor,
Mitra,
Degrado,
Shu,
Klopp,
Cai,
Blake,
Chan,
Pasternak,
Yang,
Patchett,
Smith,
Chapman,
Schaeffer,
Burkart,
Wang,
Radons,
Heller,
Herceg,
Stingl,
Wagner,
Kolb,
Shiota,
Moore,
Galassetti,
Monohan,
Neal,
Shulman,
Cherrington,
Polonsky,
Semenkovich,
Berggren,
Yang,
Murakami,
Efanov,
Uhles,
Köhler,
Moede,
Fernström,
Appelskog,
Aspinwall,
Zaitsev,
Larsson,
de Vargas,
Fecher-Trost,
Weissgerber,
Ludwig,
Leibiger,
Juntti-Berggren,
Barker,
Gromada,
Freichel,
Leibiger,
Flockerzi,
- Pathophysiology of insulin resistance in human disease. Reaven, G.M. Physiol. Rev. (1995)
- Toward understanding the assembly and structure of KATP channels. Aguilar-Bryan, L., Clement, J.P., Gonzalez, G., Kunjilwar, K., Babenko, A., Bryan, J. Physiol. Rev. (1998)
- Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals. Bain, S.C., Prins, J.B., Hearne, C.M., Rodrigues, N.R., Rowe, B.R., Pritchard, L.E., Ritchie, R.J., Hall, J.R., Undlien, D.E., Ronningen, K.S. Nat. Genet. (1992)
- Loss of functional KATP channels in pancreatic beta-cells causes persistent hyperinsulinemic hypoglycemia of infancy. Kane, C., Shepherd, R.M., Squires, P.E., Johnson, P.R., James, R.F., Milla, P.J., Aynsley-Green, A., Lindley, K.J., Dunne, M.J. Nat. Med. (1996)
- Pancreatic expression of interferon-gamma protects mice from lethal coxsackievirus B3 infection and subsequent myocarditis. Horwitz, M.S., La Cava, A., Fine, C., Rodriguez, E., Ilic, A., Sarvetnick, N. Nat. Med. (2000)
- Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice. Seufert, J., Kieffer, T.J., Habener, J.F. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans. Dobbins, R.L., Chester, M.W., Daniels, M.B., McGarry, J.D., Stein, D.T. Diabetes (1998)
- Morphine, opioid peptides, and pancreatic islet function. Giugliano, D. Diabetes Care (1984)
- Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass. Hashimoto, N., Kido, Y., Uchida, T., Asahara, S., Shigeyama, Y., Matsuda, T., Takeda, A., Tsuchihashi, D., Nishizawa, A., Ogawa, W., Fujimoto, Y., Okamura, H., Arden, K.C., Herrera, P.L., Noda, T., Kasuga, M. Nat. Genet. (2006)
- Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis. Berggren, P.O., Yang, S.N., Murakami, M., Efanov, A.M., Uhles, S., Köhler, M., Moede, T., Fernström, A., Appelskog, I.B., Aspinwall, C.A., Zaitsev, S.V., Larsson, O., de Vargas, L.M., Fecher-Trost, C., Weissgerber, P., Ludwig, A., Leibiger, B., Juntti-Berggren, L., Barker, C.J., Gromada, J., Freichel, M., Leibiger, I.B., Flockerzi, V. Cell (2004)
- Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nakae, J., Biggs, W.H., Kitamura, T., Cavenee, W.K., Wright, C.V., Arden, K.C., Accili, D. Nat. Genet. (2002)
- Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Pelengaris, S., Khan, M., Evan, G.I. Cell (2002)
- The pancreatic beta cell heats up: UCP2 and insulin secretion in diabetes. Polonsky, K.S., Semenkovich, C.F. Cell (2001)
- Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells. Unger, R.H. Science (1991)
- Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. Matsuoka, T., Kajimoto, Y., Watada, H., Kaneto, H., Kishimoto, M., Umayahara, Y., Fujitani, Y., Kamada, T., Kawamori, R., Yamasaki, Y. J. Clin. Invest. (1997)
- Expression of constitutively activated Gialpha2 in vivo ameliorates streptozotocin-induced diabetes. Zheng, X.L., Guo, J., Wang, H., Malbon, C.C. J. Biol. Chem. (1998)
- Impaired insulin biosynthetic capacity in a rat model for non-insulin-dependent diabetes. Studies with dexamethasone. Giddings, S.J., Orland, M.J., Weir, G.C., Bonner-Weir, S., Permutt, M.A. Diabetes (1985)
- Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog. Shiota, M., Moore, M.C., Galassetti, P., Monohan, M., Neal, D.W., Shulman, G.I., Cherrington, A.D. Diabetes (2002)
- Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Yamagata, K., Furuta, H., Oda, N., Kaisaki, P.J., Menzel, S., Cox, N.J., Fajans, S.S., Signorini, S., Stoffel, M., Bell, G.I. Nature (1996)
- Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Pende, M., Kozma, S.C., Jaquet, M., Oorschot, V., Burcelin, R., Le Marchand-Brustel, Y., Klumperman, J., Thorens, B., Thomas, G. Nature (2000)
- Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells. Ashcroft, F.M., Harrison, D.E., Ashcroft, S.J. Nature (1984)
- Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Wilson, S.B., Kent, S.C., Patton, K.T., Orban, T., Jackson, R.A., Exley, M., Porcelli, S., Schatz, D.A., Atkinson, M.A., Balk, S.P., Strominger, J.L., Hafler, D.A. Nature (1998)
- Pharmacological agents that directly modulate insulin secretion. Doyle, M.E., Egan, J.M. Pharmacol. Rev. (2003)
- T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E. Burkly, L.C., Lo, D., Kanagawa, O., Brinster, R.L., Flavell, R.A. Nature (1989)
- Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Rohrer, S.P., Birzin, E.T., Mosley, R.T., Berk, S.C., Hutchins, S.M., Shen, D.M., Xiong, Y., Hayes, E.C., Parmar, R.M., Foor, F., Mitra, S.W., Degrado, S.J., Shu, M., Klopp, J.M., Cai, S.J., Blake, A., Chan, W.W., Pasternak, A., Yang, L., Patchett, A.A., Smith, R.G., Chapman, K.T., Schaeffer, J.M. Science (1998)
- MHC antigen induction by interferon gamma on cultured mouse pancreatic beta cells and macrophages. Genetic analysis of strain differences and discovery of an "occult" class I-like antigen in NOD/Lt mice. Leiter, E.H., Christianson, G.J., Serreze, D.V., Ting, A.T., Worthen, S.M. J. Exp. Med. (1989)
- Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept. Holz, G.G., Habener, J.F. Trends Biochem. Sci. (1992)
- Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Kulkarni, R.N., Brüning, J.C., Winnay, J.N., Postic, C., Magnuson, M.A., Kahn, C.R. Cell (1999)
- Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. Solimena, M., Folli, F., Aparisi, R., Pozza, G., De Camilli, P. N. Engl. J. Med. (1990)
- A clathrin-coated, Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin. Orci, L., Halban, P., Amherdt, M., Ravazzola, M., Vassalli, J.D., Perrelet, A. Cell (1984)
- Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin. Burkart, V., Wang, Z.Q., Radons, J., Heller, B., Herceg, Z., Stingl, L., Wagner, E.F., Kolb, H. Nat. Med. (1999)
- Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells. Smith, P.A., Rorsman, P., Ashcroft, F.M. Nature (1989)
- Disruption of IRS-2 causes type 2 diabetes in mice. Withers, D.J., Gutierrez, J.S., Towery, H., Burks, D.J., Ren, J.M., Previs, S., Zhang, Y., Bernal, D., Pons, S., Shulman, G.I., Bonner-Weir, S., White, M.F. Nature (1998)
- Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Tuttle, R.L., Gill, N.S., Pugh, W., Lee, J.P., Koeberlein, B., Furth, E.E., Polonsky, K.S., Naji, A., Birnbaum, M.J. Nat. Med. (2001)
- Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Inagaki, N., Gonoi, T., Clement, J.P., Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S., Bryan, J. Science (1995)
- Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Sund, N.J., Vatamaniuk, M.Z., Casey, M., Ang, S.L., Magnuson, M.A., Stoffers, D.A., Matschinsky, F.M., Kaestner, K.H. Genes Dev. (2001)
- The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. Kitamura, T., Nakae, J., Kitamura, Y., Kido, Y., Biggs, W.H., Wright, C.V., White, M.F., Arden, K.C., Accili, D. J. Clin. Invest. (2002)
- Therapy for persistent hyperinsulinemic hypoglycemia of infancy. Understanding the responsiveness of beta cells to diazoxide and somatostatin. Kane, C., Lindley, K.J., Johnson, P.R., James, R.F., Milla, P.J., Aynsley-Green, A., Dunne, M.J. J. Clin. Invest. (1997)
- Repeated glucose stimulation reveals distinct and lasting secretion patterns of individual rat pancreatic B cells. Giordano, E., Bosco, D., Cirulli, V., Meda, P. J. Clin. Invest. (1991)
- Chick embryo pancreatic transplants reverse experimental diabetes of rats. Eloy, R., Haffen, K., Kedinger, M., Grenier, J.F. J. Clin. Invest. (1979)
- Conserved transducer coupling but different effector linkage upon expression of the myeloid fMet-Leu-Phe receptor in insulin secreting cells. Lang, J., Boulay, F., Li, G., Wollheim, C.B. EMBO J. (1993)
- Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain. Christgau, S., Aanstoot, H.J., Schierbeck, H., Begley, K., Tullin, S., Hejnaes, K., Baekkeskov, S. J. Cell Biol. (1992)