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Chemical Compound Review:

AC1O5D94 fluoro-oxo-propan-2-yloxy- phosphanium

Synonyms: fluoro-oxo-propan-2-yloxyphosphanium

Damodaran, T.V. et al., Jones, K.H. et al.

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We carried out a time-course study on the effects of a single intramuscular (i.m.) dose (0.5x LD(50)) of sarin (O-isopropyl methylphosphonofluoridate), also known as nerve agent GB, on the mRNA expression of acetylcholinesterase (AChE) in the brain of male Sprague-Dawley rats [1].
Subchronic neurotoxic effects of sarin (O-isopropyl methylphosphonofluoridate) treatment at various doses in male Sprague Dawley rats were studied [2].

References

Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in the rat central nervous system. Damodaran, T.V., Jones, K.H., Patel, A.G., Abou-Donia, M.B. Biochem. Pharmacol. (2003) [Pubmed]
Subchronic effects following a single sarin exposure on blood-brain and blood-testes barrier permeability, acetylcholinesterase, and acetylcholine receptors in the central nervous system of rat: a dose-response study. Jones, K.H., Dechkovskaia, A.M., Herrick, E.A., Abdel-Rahman, A.A., Khan, W.A., Abou-Donia, M.B. J. Toxicol. Environ. Health Part A (2000) [Pubmed]

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