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Gene Review

Ache  -  acetylcholinesterase

Rattus norvegicus

Synonyms: AChE, Acetylcholinesterase
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Disease relevance of Ache


Psychiatry related information on Ache


High impact information on Ache


Chemical compound and disease context of Ache


Biological context of Ache


Anatomical context of Ache

  • Peak inhibition of maternal spinal cord AChE and BuChE activities occurred 2 h and 1 h after dosing, respectively [25].
  • Subchronic effects following a single sarin exposure on blood-brain and blood-testes barrier permeability, acetylcholinesterase, and acetylcholine receptors in the central nervous system of rat: a dose-response study [22].
  • The acetylcholinesterase activity was measured in erythrocytes and in different brain regions (frontal cortex--FC, pontomedullar area--PM, basal ganglia--BG) [26].
  • The concentration of exogenous ACh needed to reduce the spontaneous frequency of contractions of the isolated right atrium by 30, 60, or 90/min fell by 78%, 79% and 84% respectively after BW 284 C51 inhibition of AChE and by 95%, 94% and 94% after simultaneous inhibition of AChE and BuChE [27].
  • These results indicate that rat liver expresses several molecular forms of AChE which have multiple interactions with membranes and that liver is unlikely to be the source of the G4 form of BuChE present in high concentration in the plasma [28].

Associations of Ache with chemical compounds


Physical interactions of Ache


Co-localisations of Ache


Regulatory relationships of Ache


Other interactions of Ache


Analytical, diagnostic and therapeutic context of Ache


  1. Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors. Yang, Z.P., Dettbarn, W.D. Biochem. Pharmacol. (1998) [Pubmed]
  2. Neuronal differentiation in PC12 cells is inhibited by chlorpyrifos and its metabolites: is acetylcholinesterase inhibition the site of action? Das, K.P., Barone, S. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  3. Modulation of impaired cholinesterase activity in experimental diabetes: effect of Gymnema montanum leaf extract. Ramkumar, K.M., Latha, M., Ashokkumar, N., Pari, L., Ananthan, R. Journal of basic and clinical physiology and pharmacology. (2005) [Pubmed]
  4. Identification of the probable site of synthesis of butyrylcholinesterase in the superior cervical and ciliary ganglia of the cat. Uchida, E., Koelle, G.B. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  5. Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus. Chacón, M.A., Reyes, A.E., Inestrosa, N.C. J. Neurochem. (2003) [Pubmed]
  6. Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease. Camps, P., El Achab, R., Görbig, D.M., Morral, J., Muñoz-Torrero, D., Badia, A., Eladi Baños, J., Vivas, N.M., Barril, X., Orozco, M., Luque, F.J. J. Med. Chem. (1999) [Pubmed]
  7. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Cheng, D.H., Tang, X.C. Pharmacol. Biochem. Behav. (1998) [Pubmed]
  8. N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity. Kikuchi, T., Zhang, M.R., Ikota, N., Fukushi, K., Okamura, T., Suzuki, K., Arano, Y., Irie, T. J. Med. Chem. (2005) [Pubmed]
  9. Acetylcholinesterase activity in regions of the rat brain following a convulsion. Appleyard, M.E., Green, A.R., Smith, A.D. J. Neurochem. (1986) [Pubmed]
  10. 2,4-Dichlorophenoxyacetic acid (2,4-D) reduces acetylcholinesterase activity in rat muscle. Bernard, P.A., Toyoshima, E., Eccles, C.U., Mayer, R.F., Johnson, K.P., Max, S.R. Exp. Neurol. (1985) [Pubmed]
  11. Manipulation of myogenesis in vitro: reversible inhibition by DMSO. Blau, H.M., Epstein, C.J. Cell (1979) [Pubmed]
  12. Functional innervation of cultured hippocampal neurones by cholinergic afferents from co-cultured septal explants. Gahwiler, B.H., Brown, D.A. Nature (1985) [Pubmed]
  13. Ultrastructural localization of choline acetyltransferase in vascular endothelial cells in rat brain. Parnavelas, J.G., Kelly, W., Burnstock, G. Nature (1985) [Pubmed]
  14. The neostriatal mosaic: compartmentalization of corticostriatal input and striatonigral output systems. Gerfen, C.R. Nature (1984) [Pubmed]
  15. Substance P in the ascending cholinergic reticular system. Vincent, S.R., Satoh, K., Armstrong, D.M., Fibiger, H.C. Nature (1983) [Pubmed]
  16. Interaction of cycloheximide and diisopropylphosphorofluoridate (DFP) during subchronic administration in rat. Gupta, R.C., Dettbarn, W.D. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  17. iso-OMPA-induced potentiation of soman toxicity in rat. Gupta, R.C., Dettbarn, W.D. Arch. Toxicol. (1987) [Pubmed]
  18. Intrastriatal hypoxanthine administration affects Na(+),K(+)-ATPase, acetylcholinesterase and catalase activities in striatum, hippocampus and cerebral cortex of rats. Bavaresco, C.S., Chiarani, F., Wajner, M., Netto, C.A., de Souza Wyse, A.T. Int. J. Dev. Neurosci. (2006) [Pubmed]
  19. Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury. Xiao, X.Q., Yang, J.W., Tang, X.C. Neurosci. Lett. (1999) [Pubmed]
  20. Regulation of the rat oligodendroglia cell line OLN-93 by antisense transfection of butyrylcholinesterase. Robitzki, A., Döll, F., Richter-Landsberg, C., Layer, P.G. Glia (2000) [Pubmed]
  21. Effects of hypophysectomy on acetylcholinesterase and butyrylcholinesterase in the rat. Edwards, J.A., Brimijoin, S. Biochem. Pharmacol. (1983) [Pubmed]
  22. Subchronic effects following a single sarin exposure on blood-brain and blood-testes barrier permeability, acetylcholinesterase, and acetylcholine receptors in the central nervous system of rat: a dose-response study. Jones, K.H., Dechkovskaia, A.M., Herrick, E.A., Abdel-Rahman, A.A., Khan, W.A., Abou-Donia, M.B. J. Toxicol. Environ. Health Part A (2000) [Pubmed]
  23. Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives. Rampa, A., Bisi, A., Valenti, P., Recanatini, M., Cavalli, A., Andrisano, V., Cavrini, V., Fin, L., Buriani, A., Giusti, P. J. Med. Chem. (1998) [Pubmed]
  24. Vascular cholinesterases and choline uptake in isolated rat forebrain microvessels: a possible link. Shimon, M., Egozi, Y., Kloog, Y., Sokolovsky, M., Cohen, S. J. Neurochem. (1989) [Pubmed]
  25. Inhibition and recovery of maternal and fetal cholinesterase enzymes following a single oral dose of chlorpyrifos in rats. Ashry, K.M., Abu-Qare, A.W., Saleem, F.R., Hussein, Y.A., Hamza, S.M., Kishk, A.M., Abou-Donia, M.B. Arch. Toxicol. (2002) [Pubmed]
  26. Relationship between plasmatic levels of sarin and cholinesterase inhibition in rats exposed to sarin vapors. Sevelová, L., Bajgar, J., Bielavská, M. Cent. Eur. J. Public Health (2004) [Pubmed]
  27. Acetylcholinesterase and butyrylcholinesterase activity in the atria of the heart of adult albino rats. Slavíková, J., Vlk, J., Hlavicková, V. Physiologia Bohemoslovaca. (1982) [Pubmed]
  28. Differential association and distribution of acetyl- and butyrylcholinesterases within rat liver subcellular organelles. Perelman, A., Abeijon, C., Hirschberg, C.B., Inestrosa, N.C., Brandan, E. J. Biol. Chem. (1990) [Pubmed]
  29. Homodimeric tacrine congeners as acetylcholinesterase inhibitors. Hu, M.K., Wu, L.J., Hsiao, G., Yen, M.H. J. Med. Chem. (2002) [Pubmed]
  30. Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design. Hammond, P.I., Kern, C., Hong, F., Kollmeyer, T.M., Pang, Y.P., Brimijoin, S. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  31. Changes in the levels and forms of rat plasma cholinesterases during chronic diisopropylphosphorofluoridate intoxication. Traina, M.E., Serpietri, L.A. Biochem. Pharmacol. (1984) [Pubmed]
  32. Acetyl- and butyrylcholinesterase activities in the rat retina and retinal pigment epithelium. Sánchez-Chávez, G., Vidal, C.J., Salceda, R. J. Neurosci. Res. (1995) [Pubmed]
  33. Butyrylcholinesterase-rich neurons in rat brain demonstrated by a sensitive histochemical method. Tago, H., Maeda, T., McGeer, P.L., Kimura, H. J. Comp. Neurol. (1992) [Pubmed]
  34. Transplants of Schwann cell cultures promote axonal regeneration in the adult mammalian brain. Kromer, L.F., Cornbrooks, C.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  35. Distribution of neurotensin binding sites in rat brain: a light microscopic radioautographic study using monoiodo [125I]Tyr3-neurotensin. Moyse, E., Rostène, W., Vial, M., Leonard, K., Mazella, J., Kitabgi, P., Vincent, J.P., Beaudet, A. Neuroscience (1987) [Pubmed]
  36. Calcium-binding proteins in the periglomerular region of typical and typical olfactory glomeruli. Crespo, C., Alonso, J.R., Briñón, J.G., Weruaga, E., Porteros, A., Arévalo, R., Aijón, J. Brain Res. (1997) [Pubmed]
  37. A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models. Hu, Y., Xia, Z., Sun, Q., Orsi, A., Rees, D. Brain Res. (2005) [Pubmed]
  38. Effects of ginsenoside Rb1 on central cholinergic metabolism. Benishin, C.G., Lee, R., Wang, L.C., Liu, H.J. Pharmacology (1991) [Pubmed]
  39. Peptidergic innervation of the rat Harderian gland. Tsukahara, S., Jacobowitz, D.M. Histochemistry (1987) [Pubmed]
  40. Ciliary neurotrophic factor: regulation of acetylcholinesterase in skeletal muscle and distribution of messenger RNA encoding its receptor in synaptic versus extrasynaptic compartments. Boudreau-Larivière, C., Sveistrup, H., Parry, D.J., Jasmin, B.J. Neuroscience (1996) [Pubmed]
  41. Interleukin-6 and leukemia inhibitory factor promote the survival of acetylcholinesterase-positive neurons in culture from embryonic rat spinal cord. Kushima, Y., Hatanaka, H. Neurosci. Lett. (1992) [Pubmed]
  42. Thyrotropin-releasing hormone selectively depresses glutamate excitation of cerebral cortical neurons. Renaud, L.P., Blume, H.W., Pittman, Q.J., Lamour, Y., Tan, A.T. Science (1979) [Pubmed]
  43. Sustained inhibition of acetylcholinesterase activity does not disrupt early geniculocortical ingrowth to developing rat visual cortex. Ling, J.J., Yu, J., Robertson, R.T. Brain Res. Dev. Brain Res. (1995) [Pubmed]
  44. Dichlorvos intoxication and gastric secretion. Maśliński, S., Ciurzyńska, G., Maślińska, D. Acta physiologica Polonica. (1979) [Pubmed]
  45. Divergent regulation of acetylcholinesterase and butyrylcholinesterase in tissues of the rat. Edwards, J.A., Brimijoin, S. J. Neurochem. (1982) [Pubmed]
  46. Ovariectomy increases Na+, K+-ATPase, acetylcholinesterase and catalase in rat hippocampus. Monteiro, S.C., Matté, C., Delwing, D., Wyse, A.T. Mol. Cell. Endocrinol. (2005) [Pubmed]
  47. Acute sarin exposure causes differential regulation of choline acetyltransferase, acetylcholinesterase, and acetylcholine receptors in the central nervous system of the rat. Khan, W.A., Dechkovskaia, A.M., Herrick, E.A., Jones, K.H., Abou-Donia, M.B. Toxicol. Sci. (2000) [Pubmed]
  48. Increased expression of glial fibrillary acidic protein in cerebellum and hippocampus: differential effects on neonatal brain regional acetylcholinesterase following maternal exposure to combined chlorpyrifos and nicotine. Abdel-Rahman, A., Dechkovskaia, A., Mehta-Simmons, H., Guan, X., Khan, W., Abou-Donia, M. J. Toxicol. Environ. Health Part A (2003) [Pubmed]
  49. Reciprocal regulation of acetylcholinesterase and butyrylcholinesterase in mammalian skeletal muscle. Berman, H.A., Decker, M.M., Jo, S. Dev. Biol. (1987) [Pubmed]
  50. Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE. Wang, H., Carlier, P.R., Ho, W.L., Wu, D.C., Lee, N.T., Li, C.P., Pang, Y.P., Han, Y.F. Neuroreport (1999) [Pubmed]
  51. A quantitative histochemistry technique for measuring regional distribution of acetylcholinesterase in the brain using digital scanning densitometry. Ma, T., Cai, Z., Wellman, S.E., Ho, I.K. Anal. Biochem. (2001) [Pubmed]
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