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Ache  -  acetylcholinesterase

Rattus norvegicus

Synonyms: AChE, Acetylcholinesterase
 
 
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Disease relevance of Ache

 

Psychiatry related information on Ache

 

High impact information on Ache

 

Chemical compound and disease context of Ache

 

Biological context of Ache

 

Anatomical context of Ache

  • Peak inhibition of maternal spinal cord AChE and BuChE activities occurred 2 h and 1 h after dosing, respectively [25].
  • Subchronic effects following a single sarin exposure on blood-brain and blood-testes barrier permeability, acetylcholinesterase, and acetylcholine receptors in the central nervous system of rat: a dose-response study [22].
  • The acetylcholinesterase activity was measured in erythrocytes and in different brain regions (frontal cortex--FC, pontomedullar area--PM, basal ganglia--BG) [26].
  • The concentration of exogenous ACh needed to reduce the spontaneous frequency of contractions of the isolated right atrium by 30, 60, or 90/min fell by 78%, 79% and 84% respectively after BW 284 C51 inhibition of AChE and by 95%, 94% and 94% after simultaneous inhibition of AChE and BuChE [27].
  • These results indicate that rat liver expresses several molecular forms of AChE which have multiple interactions with membranes and that liver is unlikely to be the source of the G4 form of BuChE present in high concentration in the plasma [28].
 

Associations of Ache with chemical compounds

 

Physical interactions of Ache

 

Co-localisations of Ache

 

Regulatory relationships of Ache

 

Other interactions of Ache

 

Analytical, diagnostic and therapeutic context of Ache

References

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  22. Subchronic effects following a single sarin exposure on blood-brain and blood-testes barrier permeability, acetylcholinesterase, and acetylcholine receptors in the central nervous system of rat: a dose-response study. Jones, K.H., Dechkovskaia, A.M., Herrick, E.A., Abdel-Rahman, A.A., Khan, W.A., Abou-Donia, M.B. J. Toxicol. Environ. Health Part A (2000) [Pubmed]
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  28. Differential association and distribution of acetyl- and butyrylcholinesterases within rat liver subcellular organelles. Perelman, A., Abeijon, C., Hirschberg, C.B., Inestrosa, N.C., Brandan, E. J. Biol. Chem. (1990) [Pubmed]
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  46. Ovariectomy increases Na+, K+-ATPase, acetylcholinesterase and catalase in rat hippocampus. Monteiro, S.C., Matté, C., Delwing, D., Wyse, A.T. Mol. Cell. Endocrinol. (2005) [Pubmed]
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