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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

CHEMBL189871     4-[2-[4-[(E)-3-(4- chlorophenyl)prop-2...

Synonyms: SureCN10899604, CHEBI:416279, AC1O5OIR, BM-15766, LS-36627, ...
 
 
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High impact information on BM 15766

  • Treatment of rats with a new hypocholesterolemic drug BM 15766 induces proliferation of peroxisomes in pericentral regions of the liver lobule with distinct alterations of the peroxisomal membrane (Baumgart, E., K. Stegmeier, F. H. Schmidt, and H. D. Fahimi. 1987. Lab. Invest. 56:554-564) [1].
  • Similarly, BM 15766 and Wy-14,643 increased transcription of the PMP68 gene in vitro, whereas PBP gene transcription was increased by Wy-14,643 but not by BM 15766 [2].
  • Another proliferator, BM 15766, caused maximal induction of PMP68 but only a low induction of PBP; further PBP induction was achieved by the administration of BM 15766 in combination with Wy-14,643 [2].
  • These observations demonstrate the marked adaptive response of rat hepatocyte organelles to severe hypocholesterolemia induced by BM 15766 [3].

References

  1. Biogenesis of peroxisomes: immunocytochemical investigation of peroxisomal membrane proteins in proliferating rat liver peroxisomes and in catalase-negative membrane loops. Baumgart, E., Völkl, A., Hashimoto, T., Fahimi, H.D. J. Cell Biol. (1989) [Pubmed]
  2. Induction of the major integral membrane protein of mouse liver peroxisomes by peroxisome proliferators. Chen, N., Crane, D.I. Biochem. J. (1992) [Pubmed]
  3. Proliferation of peroxisomes in pericentral hepatocytes of rat liver after administration of a new hypocholesterolemic agent (BM 15766). Sex-dependent ultrastructural differences. Baumgart, E., Stegmeier, K., Schmidt, F.H., Fahimi, H.D. Lab. Invest. (1987) [Pubmed]
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