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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Organelles

  • Prolonged subcultivation was accompanied by chromosomal abnormalities and eventual "crisis". Transformed cells did not exhibit endothelial-specific organelles (Weibel-Palade bodies) or factor VIII antigen, but angiotensin-converting enzyme occasionally was detectable in SVHEC cultures [1].
  • Until recently, it was thought that the D-mannose binding site was located in the major structural subunit (FimA), of relative molecular mass (Mr) 17,000 (17 K), of these organelles in Escherichia coli [2].
  • Virtually all uropathogenic strains of Escherichia coli, the primary cause of cystitis, assemble adhesive surface organelles called type 1 pili that contain the FimH adhesin [3].
  • Observed under the scanning and transmission electron microscopes, the LH-stimulated cells had well-developed cytoplasmic organelles and inclusions and surface specializations such as numerous microvilli, large blebs, and other microextensions [4].
  • We show that one such feature may be the modified nucleoside 1-methylguanosine (m(1)G37), which prevents frameshifting and is present adjacent to and 3' of the anticodon (position 37) in the same subset of tRNAs from all organisms, including that with the smallest sequenced genome (Mycoplasma genitalium), and organelles [5].

Psychiatry related information on Organelles


High impact information on Organelles

  • RNase P activities have been identified in Bacteria, Archaea, and Eucarya, as well as organelles [8].
  • Chaperones (NSF/Sec18p, LMA1, and -SNAP/Sec17p) disassemble cis-SNARE complexes to prepare for the docking of organelles rather than to drive fusion [9].
  • This paper aims to review the evidence for localization of CFTR in intracellular organelles and the potential physiological consequences of that localization [10].
  • In these organelles the enzymes may be important in the transfer of acyl groups, which are produced by the peroxisomal beta-oxidation enzymes, to the mitochondria for oxidation in the citric acid cycle [11].
  • Both human and yeast cells lacking peroxisomes due to mutations in PEX3 or PEX19 genes regenerate the organelles upon reintroduction of the corresponding wild-type version [12].

Chemical compound and disease context of Organelles


Biological context of Organelles

  • These results suggest that the HPS4 and HPS1 proteins may function in the same pathway of organelle biogenesis [18].
  • To block the disintegration of nuclei that are added later, Bcl-2 must be present during this latent period. "Apoptosis" in these extracts requires a dense organelle fraction enriched in mitochondria [19].
  • Neither N- nor O-glycosidically linked carbohydrates are involved in the transport defect of the mutant HA, because tunicamycin, an inhibitor of N-type glycosylation, has no effect, and O-type glycosylation takes place in the Golgi organelle [20].
  • HKB controls polarized cell shape change and apical membrane growth during salivary cell invagination via two downstream target genes, crumbs (crb), a determinant of the apical membrane, and klarsicht (klar), which mediates microtubule-dependent organelle transport [21].
  • Tubule formation of these organelles was specific to BFA, shared near identical pharmacologic characteristics as Golgi tubules and resulted in targeted membrane fusion [22].

Anatomical context of Organelles


Associations of Organelles with chemical compounds

  • These findings represent an unsuspected mechanism for messenger-mediated Ca(2+) release from lysosome-related organelles [28].
  • Temperature-sensitive secretory mutants (sec) of S. cerevisiae have been used to evaluate the organelles and cellular functions involved in transport of the vacuolar glycoprotein, carboxypeptidase Y (CPY) [29].
  • Brefeldin A (BFA) is a unique drug affecting the molecular mechanisms that regulate membrane traffic and organelle structure [30].
  • The properties tested, including midpoint potential, carbon monoxide binding, and organelle distribution, were normal, but the cytochrome did not undergo reduction on cellular stimulation [31].
  • Peroxisomes are cytoplasmic organelles which are important in mammals in modulation of lipid homeostasis, including the metabolism of long-chain fatty acids and conversion of cholesterol to bile salts (reviewed in refs 1 and 2) [32].

Gene context of Organelles


Analytical, diagnostic and therapeutic context of Organelles


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  3. Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination. Langermann, S., Palaszynski, S., Barnhart, M., Auguste, G., Pinkner, J.S., Burlein, J., Barren, P., Koenig, S., Leath, S., Jones, C.H., Hultgren, S.J. Science (1997) [Pubmed]
  4. Structural and functional factors related to testicular neoplasia in feminized rats. Chung, K.W., Allison, J.E., Stanley, A.J. J. Natl. Cancer Inst. (1980) [Pubmed]
  5. A primordial tRNA modification required for the evolution of life? Björk, G.R., Jacobsson, K., Nilsson, K., Johansson, M.J., Byström, A.S., Persson, O.P. EMBO J. (2001) [Pubmed]
  6. Protein processing in lysosomes: the new therapeutic target in neurodegenerative disease. Mayer, R.J., Landon, M., Laszlo, L., Lennox, G., Lowe, J. Lancet (1992) [Pubmed]
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  12. Contribution of the endoplasmic reticulum to peroxisome formation. Hoepfner, D., Schildknegt, D., Braakman, I., Philippsen, P., Tabak, H.F. Cell (2005) [Pubmed]
  13. Novel N-terminal amino acid sequence required for retention of a hepatitis B virus glycoprotein in the endoplasmic reticulum. Kuroki, K., Russnak, R., Ganem, D. Mol. Cell. Biol. (1989) [Pubmed]
  14. A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis. Huang, X., Suyama, K., Buchanan, J., Zhu, A.J., Scott, M.P. Development (2005) [Pubmed]
  15. Photosensitization by 3,3'-dihexyloxacarbocyanine iodide: specific disruption of microtubules and inactivation of organelle motility. Lee, C., Wu, S.S., Chen, L.B. Cancer Res. (1995) [Pubmed]
  16. Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: a laser scanning confocal microscopic study. Zahrebelski, G., Nieminen, A.L., al-Ghoul, K., Qian, T., Herman, B., Lemasters, J.J. Hepatology (1995) [Pubmed]
  17. A mechanism for tamoxifen-mediated inhibition of acidification. Chen, Y., Schindler, M., Simon, S.M. J. Biol. Chem. (1999) [Pubmed]
  18. Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene. Suzuki, T., Li, W., Zhang, Q., Karim, A., Novak, E.K., Sviderskaya, E.V., Hill, S.P., Bennett, D.C., Levin, A.V., Nieuwenhuis, H.K., Fong, C.T., Castellan, C., Miterski, B., Swank, R.T., Spritz, R.A. Nat. Genet. (2002) [Pubmed]
  19. Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Newmeyer, D.D., Farschon, D.M., Reed, J.C. Cell (1994) [Pubmed]
  20. Analysis of the hemagglutinin glycoprotein from mutants of vaccinia virus that accumulates on the nuclear envelope. Shida, H., Matsumoto, S. Cell (1983) [Pubmed]
  21. Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane. Myat, M.M., Andrew, D.J. Cell (2002) [Pubmed]
  22. Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Lippincott-Schwartz, J., Yuan, L., Tipper, C., Amherdt, M., Orci, L., Klausner, R.D. Cell (1991) [Pubmed]
  23. Localization of serum-derived alpha 2 macroglobulin in cultured cells and decrease after Moloney sarcoma virus transformation. Pastan, I., Willingham, M., Anderson, W., Gallo, M. Cell (1977) [Pubmed]
  24. Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Kornak, U., Kasper, D., Bösl, M.R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G., Jentsch, T.J. Cell (2001) [Pubmed]
  25. The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol. Dammai, V., Subramani, S. Cell (2001) [Pubmed]
  26. Identification of the familial cylindromatosis tumour-suppressor gene. Bignell, G.R., Warren, W., Seal, S., Takahashi, M., Rapley, E., Barfoot, R., Green, H., Brown, C., Biggs, P.J., Lakhani, S.R., Jones, C., Hansen, J., Blair, E., Hofmann, B., Siebert, R., Turner, G., Evans, D.G., Schrander-Stumpel, C., Beemer, F.A., van Den Ouweland, A., Halley, D., Delpech, B., Cleveland, M.G., Leigh, I., Leisti, J., Rasmussen, S. Nat. Genet. (2000) [Pubmed]
  27. Cytoplasmic dynein is a minus end-directed motor for membranous organelles. Schroer, T.A., Steuer, E.R., Sheetz, M.P. Cell (1989) [Pubmed]
  28. NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs. Churchill, G.C., Okada, Y., Thomas, J.M., Genazzani, A.A., Patel, S., Galione, A. Cell (2002) [Pubmed]
  29. Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole. Stevens, T., Esmon, B., Schekman, R. Cell (1982) [Pubmed]
  30. A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1. Hsu, V.W., Shah, N., Klausner, R.D. Cell (1992) [Pubmed]
  31. Absence of cytochrome b-245 in chronic granulomatous disease. A multicenter European evaluation of its incidence and relevance. Segal, A.W., Cross, A.R., Garcia, R.C., Borregaard, N., Valerius, N.H., Soothill, J.F., Jones, O.T. N. Engl. J. Med. (1983) [Pubmed]
  32. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Kliewer, S.A., Umesono, K., Noonan, D.J., Heyman, R.A., Evans, R.M. Nature (1992) [Pubmed]
  33. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Li, W., Zhang, Q., Oiso, N., Novak, E.K., Gautam, R., O'Brien, E.P., Tinsley, C.L., Blake, D.J., Spritz, R.A., Copeland, N.G., Jenkins, N.A., Amato, D., Roe, B.A., Starcevic, M., Dell'Angelica, E.C., Elliott, R.W., Mishra, V., Kingsmore, S.F., Paylor, R.E., Swank, R.T. Nat. Genet. (2003) [Pubmed]
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  36. Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Gunawardena, S., Goldstein, L.S. Neuron (2001) [Pubmed]
  37. Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias. Acute regulation of CFTR trafficking in an intact epithelium. Lehrich, R.W., Aller, S.G., Webster, P., Marino, C.R., Forrest, J.N. J. Clin. Invest. (1998) [Pubmed]
  38. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Dyck, J.A., Maul, G.G., Miller, W.H., Chen, J.D., Kakizuka, A., Evans, R.M. Cell (1994) [Pubmed]
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  40. Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. Miyoshi, K., Shillingford, J.M., Smith, G.H., Grimm, S.L., Wagner, K.U., Oka, T., Rosen, J.M., Robinson, G.W., Hennighausen, L. J. Cell Biol. (2001) [Pubmed]
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