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Chemical Compound Review

KOS-953     [ (3S,5S,6R,7S,8E,10R,11S,12E,14 E)-6...

Synonyms: CHEMBL126955, CCRIS 9401, BMS-722782, DNC000034, NSC330507, ...
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High impact information on NSC 330507

  • 17-allylamino, 17-demethoxygeldanamycin (17AAG; NSC 330507) is the first modulator of heat shock protein 90 (Hsp90) to enter clinical trials [1].

Analytical, diagnostic and therapeutic context of NSC 330507

  • One of these agents, 17-allylamino,17-demethoxygeldanamycin (NSC 330507) has begun phase II clinical trials, and several second-generation compounds are now in late preclinical development [2].


  1. Clinical development of 17-allylamino, 17-demethoxygeldanamycin. Sausville, E.A., Tomaszewski, J.E., Ivy, P. Current cancer drug targets. (2003) [Pubmed]
  2. Altered Hsp90 function in cancer: a unique therapeutic opportunity. Bagatell, R., Whitesell, L. Mol. Cancer Ther. (2004) [Pubmed]
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