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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Clinical Trials

 
 
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Disease relevance of Clinical Trials

 

Psychiatry related information on Clinical Trials

 

High impact information on Clinical Trials

 

Chemical compound and disease context of Clinical Trials

 

Biological context of Clinical Trials

 

Anatomical context of Clinical Trials

 

Associations of Clinical Trials with chemical compounds

 

Gene context of Clinical Trials

  • Several clinical trials using a chimeric anti-TNF alpha antibody have shown marked clinical benefit, verifying the hypothesis that TNF alpha is of major importance in rheumatoid arthritis [12].
  • Clinical trials are now testing whether mammalian target of rapamycin (mTOR) inhibition is useful in treating PTEN-null cancers [35].
  • Clinical trials with various VEGF inhibitors in a variety of malignancies are ongoing [36].
  • IMPLICATIONS: Enhanced drug accumulation in nonmalignant tissues after Pgp blockade should be carefully considered in future clinical trials of Pgp modulation [37].
  • IMPLICATIONS: Clinical trials with anti-EGF receptor MAbs are being conducted, and trials with anti-EGF receptor MAbs combined with doxorubicin are planned [38].
 

Analytical, diagnostic and therapeutic context of Clinical Trials

References

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  37. Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice. van Asperen, J., Schinkel, A.H., Beijnen, J.H., Nooijen, W.J., Borst, P., van Tellingen, O. J. Natl. Cancer Inst. (1996) [Pubmed]
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