Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-K-44793 (3S,8S,9S,10R,13R,14S,17R)- 10,13-dimethyl...

Synonyms: KB-251174, AKOS015896877, NSC 137837, AC1L22JA, AK112140, ...

Zhou, G. et al., Tanaka, M. et al.

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High impact information on AI3-24121

Antioxidant activity of thiocholesterol on copper-induced oxidation of low-density lipoprotein [1].
Thus, thiocholesterol exhibits approx. 10% of the substrate efficiency of cholesterol when incubated with pure human LCAT [2].
Thiocholesterol was a good terminal fatty acyl acceptor when incorporated into synthetic proteoliposomes containing lecithin/thiocholesterol/apo A-I in the molar ratios of 250:15:0 [2].

Gene context of AI3-24121

We conclude that LCAT can transacylate a fatty acyl moiety from the sn-2 position of lecithin to the 3 beta-SH group of thiocholesterol forming a cholesteryl thioester [2].

References

Antioxidant activity of thiocholesterol on copper-induced oxidation of low-density lipoprotein. Tanaka, M., Nakagawa, M. Lipids (1995) [Pubmed]
Human plasma lecithin:cholesterol acyltransferase. On the substrate efficiency of cholest-5-ene-3 beta-thiol as a fatty acyl acceptor. Zhou, G., Dolphin, P.J. Biochim. Biophys. Acta (1995) [Pubmed]

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