Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-D-65009 2-methylbut-2-enoic acid

Synonyms: AG-L-64886, ACMC-209ltc, ACMC-209pjt, ANW-32542, ANW-37383, ...

Moberg, V. et al., Teychenne, P.F. et al.

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Disease relevance of C08279

2. The C-5 acids investigated were those accumulating in inborn errors of metabolism, i.e. isovaleric acid, beta-methylcrotonic acid, tiglic acid and alpha-keto- and alpha-hydroxy-isovaleric acid [1].

High impact information on C08279

The phosphine-substituted clusters were found to be able to catalyze the (asymmetric) hydrogenation of tiglic acid albeit with relatively low selectivity (enantiomeric excesses varying from 0 to 23%) [2].

References

The encephalopathic action of five-carbon-atom fatty acids in the rabbit. Teychenne, P.F., Walters, I., Claveria, L.E., Calne, D.B., Price, J., Macgillivary, B.B., Gompertz, D. Clinical science and molecular medicine. (1976) [Pubmed]
Synthesis, characterization and reactivity of tetranuclear ruthenium hydrido clusters containing chiral phosphine ligands. Moberg, V., Homanen, P., Selva, S., Persson, R., Haukka, M., Pakkanen, T.A., Monari, M., Nordlander, E. Dalton transactions (Cambridge, England : 2003) (2006) [Pubmed]

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