Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-0009V4 (2-hydroxy-3-oxo- butoxy)phosphonic acid

Synonyms: AG-K-62591, ACMC-20mju8, CHEBI:50606, CTK0G1048, AC1L19R5, ...

Lee, C.Y. et al., Worst, D.J. et al., Liao, D.I. et al.

Liao, Zheng, Viitanen, Jordan,

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Disease relevance of NSC102628

Sequence analyses and complementation of Escherichia coli riboflavin auxotrophs showed that the gene products of ribB and ribA are 3,4-dihydroxy-2-butanone 4-phosphate (DHBP) synthetase and GTP cyclohydrolase II, respectively [1].

High impact information on NSC102628

Structural definition of the active site and catalytic mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase [2].
This gene encodes a bifunctional enzyme with the activities of both 3,4-dihydroxy-2-butanone 4-phosphate (DHBP) synthase and GTP cyclohydrolase II, which catalyze two essential steps in riboflavin biosynthesis [3].

References

Riboflavin synthesis genes are linked with the lux operon of Photobacterium phosphoreum. Lee, C.Y., O'Kane, D.J., Meighen, E.A. J. Bacteriol. (1994) [Pubmed]
Structural definition of the active site and catalytic mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase. Liao, D.I., Zheng, Y.J., Viitanen, P.V., Jordan, D.B. Biochemistry (2002) [Pubmed]
Helicobacter pylori ribBA-mediated riboflavin production is involved in iron acquisition. Worst, D.J., Gerrits, M.M., Vandenbroucke-Grauls, C.M., Kusters, J.G. J. Bacteriol. (1998) [Pubmed]

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