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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Lustral     (1S,4S)-4-(3,4- dichlorophenyl)-N-methyl-1...

Synonyms: Sertralina, Zoloft, sertraline, Sertralinum, Apo-Sertraline, ...
 
 
 
 
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Disease relevance of sertraline

  • A and S significantly improved Fibromyalgia Impact Questionnaire (FIQ) pain scores, Hamilton anxiety and depression rating scales [1].
 

High impact information on sertraline

  • The effect of amitriptyline (A, 20 mg daily) and sertraline (S, 100 mg daily) treatment on patients' superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (ADA) enzyme activities, thiobarbituric acid reactive substances (TBARS) and NO levels was investigated [1].
  • But neither A nor S had significant effects on measured oxidative stress parameters, except SOD activity that was significantly reduced after S treatment [1].

References

  1. Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns. Ozgocmen, S., Ozyurt, H., Sogut, S., Akyol, O., Ardicoglu, O., Yildizhan, H. Rheumatol. Int. (2006) [Pubmed]
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