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Chemical Compound Review

Beleodaq     (E)-N-hydroxy-3-[3- (phenylsulfamoyl)phenyl...

Synonyms: Belinostat, PubChem22405, PDX-101, PXD-101, QCR-181, ...
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Disease relevance of Belinostat


Associations of Belinostat with other chemical compounds

  • In a severe combined immunodeficient beige mouse model of MCL, the addition of belinostat to bortezomib enhanced efficacy compared with either drug alone [2].


  1. A phase I/II trial of belinostat in combination with cisplatin, doxorubicin, and cyclophosphamide in thymic epithelial tumors: a clinical and translational study. Thomas, A., Rajan, A., Szabo, E., Tomita, Y., Carter, C.A., Scepura, B., Lopez-Chavez, A., Lee, M.J., Redon, C.E., Frosch, A., Peer, C.J., Chen, Y., Piekarz, R., Steinberg, S.M., Trepel, J.B., Figg, W.D., Schrump, D.S., Giaccone, G. Clin. Cancer Res. (2014) [Pubmed]
  2. Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma. Paoluzzi, L., Scotto, L., Marchi, E., Zain, J., Seshan, V.E., O'Connor, O.A. Clin. Cancer Res. (2010) [Pubmed]
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