Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Beleodaq (E)-N-hydroxy-3-[3- (phenylsulfamoyl)phenyl...

Synonyms: Belinostat, PubChem22405, PDX-101, PXD-101, QCR-181, ...

Thomas, A. et al., Paoluzzi, L. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Belinostat

Dose-limiting toxicities at 2,000 mg/m(2) belinostat were grade 3 nausea and diarrhea and grade 4 neutropenia and thrombocytopenia, respectively, in two patients [1].

Associations of Belinostat with other chemical compounds

In a severe combined immunodeficient beige mouse model of MCL, the addition of belinostat to bortezomib enhanced efficacy compared with either drug alone [2].

References

A phase I/II trial of belinostat in combination with cisplatin, doxorubicin, and cyclophosphamide in thymic epithelial tumors: a clinical and translational study. Thomas, A., Rajan, A., Szabo, E., Tomita, Y., Carter, C.A., Scepura, B., Lopez-Chavez, A., Lee, M.J., Redon, C.E., Frosch, A., Peer, C.J., Chen, Y., Piekarz, R., Steinberg, S.M., Trepel, J.B., Figg, W.D., Schrump, D.S., Giaccone, G. Clin. Cancer Res. (2014) [Pubmed]
Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma. Paoluzzi, L., Scotto, L., Marchi, E., Zain, J., Seshan, V.E., O'Connor, O.A. Clin. Cancer Res. (2010) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share