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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Neutropenia


Psychiatry related information on Neutropenia


High impact information on Neutropenia


Chemical compound and disease context of Neutropenia

  • Of 550 evaluable episodes of fever and neutropenia, 282 were treated with ceftazidime alone and 268 with the combination [15].
  • Treatment was discontinued in 11 ganciclovir recipients and 1 placebo recipient because of neutropenia (P = 0.003) [16].
  • Lithium carbonate in chemotherapy-induced neutropenia [17].
  • When the patients who actually received the escalated doses of doxorubicin were compared with the patients in the s-BACOP group in whom neutropenia did not develop during the first treatment cycle, no difference between their outcomes was observed [18].
  • The reduced daily dose of zidovudine used in this study was at least as effective as the standard dose and was less toxic; however, with the use of a four-week induction period with a high dose followed by low-dose treatment, severe anemia and neutropenia were common complications of treatment with zidovudine [19].
  • The UGT1A1*28/*28 genotype was associated with an increased risk of neutropenia not only at medium or high doses of irinotecan but also at low doses [20].

Biological context of Neutropenia


Anatomical context of Neutropenia


Gene context of Neutropenia

  • Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia [30].
  • In approximately 20% of cases of severe congenital neutropenia (SCN), mutations are found in the gene encoding the granulocyte colony-stimulating factor receptor (G-CSF-R) [31].
  • Cohen syndrome is an autosomal recessive condition associated with developmental delay, facial dysmorphism, pigmentary retinopathy, and neutropenia [32].
  • In summary, gibbon IL-3 is a growth factor that can synergize with other CSFs to enhance proliferation of myeloid-committed progenitors, suggesting that combinations of CSFs may have clinical utility in patients with neutropenia of various etiologies [33].
  • Recently, we described a case of severe neonatal alloimmune neutropenia (NAIN) caused by an alloantibody against a variant of the CD11b subunit (Mart alloantigen) [34].

Analytical, diagnostic and therapeutic context of Neutropenia


  1. Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases. Volberding, P.A., Lagakos, S.W., Koch, M.A., Pettinelli, C., Myers, M.W., Booth, D.K., Balfour, H.H., Reichman, R.C., Bartlett, J.A., Hirsch, M.S. N. Engl. J. Med. (1990) [Pubmed]
  2. Lethal pulmonary reactions associated with the combined use of amphotericin B and leukocyte transfusions. Wright, D.G., Robichaud, K.J., Pizzo, P.A., Deisseroth, A.B. N. Engl. J. Med. (1981) [Pubmed]
  3. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. Saltz, L.B., Cox, J.V., Blanke, C., Rosen, L.S., Fehrenbacher, L., Moore, M.J., Maroun, J.A., Ackland, S.P., Locker, P.K., Pirotta, N., Elfring, G.L., Miller, L.L. N. Engl. J. Med. (2000) [Pubmed]
  4. Granulocyte-macrophage colony-stimulating factor after initial chemotherapy for elderly patients with primary acute myelogenous leukemia. Cancer and Leukemia Group B. Stone, R.M., Berg, D.T., George, S.L., Dodge, R.K., Paciucci, P.A., Schulman, P., Lee, E.J., Moore, J.O., Powell, B.L., Schiffer, C.A. N. Engl. J. Med. (1995) [Pubmed]
  5. Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group. Walsh, T.J., Finberg, R.W., Arndt, C., Hiemenz, J., Schwartz, C., Bodensteiner, D., Pappas, P., Seibel, N., Greenberg, R.N., Dummer, S., Schuster, M., Holcenberg, J.S. N. Engl. J. Med. (1999) [Pubmed]
  6. Allelic heterogeneity in the COH1 gene explains clinical variability in Cohen syndrome. Hennies, H.C., Rauch, A., Seifert, W., Schumi, C., Moser, E., Al-Taji, E., Tariverdian, G., Chrzanowska, K.H., Krajewska-Walasek, M., Rajab, A., Giugliani, R., Neumann, T.E., Eckl, K.M., Karbasiyan, M., Reis, A., Horn, D. Am. J. Hum. Genet. (2004) [Pubmed]
  7. Choices of methodology in pharmacoeconomics studies. Longo, C.J. Medical care. (1999) [Pubmed]
  8. Olanzapine appears haematologically safe in patients who developed blood dyscrasia on clozapine and risperidone. Dernovsek, M.Z., Tavcar, R. International clinical psychopharmacology. (2000) [Pubmed]
  9. How many forms of glycogen storage disease type I? Veiga-da-Cunha, M., Gerin, I., Van Schaftingen, E. Eur. J. Pediatr. (2000) [Pubmed]
  10. Lessons learned from raltitrexed--quality assurance, patient education and intensive supportive drugs to optimise tolerability. Thomas, R.J., Williams, M., Garcia-Vargas, J. Clinical oncology (Royal College of Radiologists (Great Britain)) (2003) [Pubmed]
  11. Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Person, R.E., Li, F.Q., Duan, Z., Benson, K.F., Wechsler, J., Papadaki, H.A., Eliopoulos, G., Kaufman, C., Bertolone, S.J., Nakamoto, B., Papayannopoulou, T., Grimes, H.L., Horwitz, M. Nat. Genet. (2003) [Pubmed]
  12. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Karsunky, H., Zeng, H., Schmidt, T., Zevnik, B., Kluge, R., Schmid, K.W., Dührsen, U., Möröy, T. Nat. Genet. (2002) [Pubmed]
  13. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. Rai, K.R., Peterson, B.L., Appelbaum, F.R., Kolitz, J., Elias, L., Shepherd, L., Hines, J., Threatte, G.A., Larson, R.A., Cheson, B.D., Schiffer, C.A. N. Engl. J. Med. (2000) [Pubmed]
  14. Liposomal amphotericin B for fever and neutropenia. Wingard, J.R. N. Engl. J. Med. (1999) [Pubmed]
  15. A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia. Pizzo, P.A., Hathorn, J.W., Hiemenz, J., Browne, M., Commers, J., Cotton, D., Gress, J., Longo, D., Marshall, D., McKnight, J. N. Engl. J. Med. (1986) [Pubmed]
  16. Early treatment with ganciclovir to prevent cytomegalovirus disease after allogeneic bone marrow transplantation. Goodrich, J.M., Mori, M., Gleaves, C.A., Du Mond, C., Cays, M., Ebeling, D.F., Buhles, W.C., DeArmond, B., Meyers, J.D. N. Engl. J. Med. (1991) [Pubmed]
  17. Lithium carbonate in chemotherapy-induced neutropenia. Meisler, A.I. N. Engl. J. Med. (1977) [Pubmed]
  18. Escalated as compared with standard doses of doxorubicin in BACOP therapy for patients with non-Hodgkin's lymphoma. Meyer, R.M., Quirt, I.C., Skillings, J.R., Cripps, M.C., Bramwell, V.H., Weinerman, B.H., Gospodarowicz, M.K., Burns, B.F., Sargeant, A.M., Shepherd, L.E. N. Engl. J. Med. (1993) [Pubmed]
  19. A randomized controlled trial of a reduced daily dose of zidovudine in patients with the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group. Fischl, M.A., Parker, C.B., Pettinelli, C., Wulfsohn, M., Hirsch, M.S., Collier, A.C., Antoniskis, D., Ho, M., Richman, D.D., Fuchs, E. N. Engl. J. Med. (1990) [Pubmed]
  20. Dose-dependent association between UGT1A1*28 genotype and irinotecan-induced neutropenia: low doses also increase risk. Hu, Z.Y., Yu, Q., Pei, Q., Guo, C. Clin. Cancer Res. (2010) [Pubmed]
  21. Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase. Benson, K.F., Li, F.Q., Person, R.E., Albani, D., Duan, Z., Wechsler, J., Meade-White, K., Williams, K., Acland, G.M., Niemeyer, G., Lothrop, C.D., Horwitz, M. Nat. Genet. (2003) [Pubmed]
  22. A comparison of treatment of canine cyclic hematopoiesis with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF), G-CSF interleukin-3, and canine G-CSF. Hammond, W.P., Boone, T.C., Donahue, R.E., Souza, L.M., Dale, D.C. Blood (1990) [Pubmed]
  23. Aerosolized amphotericin B inhalations as prophylaxis of invasive aspergillus infections during prolonged neutropenia: results of a prospective randomized multicenter trial. Schwartz, S., Behre, G., Heinemann, V., Wandt, H., Schilling, E., Arning, M., Trittin, A., Kern, W.V., Boenisch, O., Bosse, D., Lenz, K., Ludwig, W.D., Hiddemann, W., Siegert, W., Beyer, J. Blood (1999) [Pubmed]
  24. Clinical relevance of point mutations in the cytoplasmic domain of the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia. Tidow, N., Pilz, C., Teichmann, B., Müller-Brechlin, A., Germeshausen, M., Kasper, B., Rauprich, P., Sykora, K.W., Welte, K. Blood (1997) [Pubmed]
  25. Hematologic abnormalities in Shwachman Diamond syndrome: lack of genotype-phenotype relationship. Kuijpers, T.W., Alders, M., Tool, A.T., Mellink, C., Roos, D., Hennekam, R.C. Blood (2005) [Pubmed]
  26. Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. Crawford, J., Ozer, H., Stoller, R., Johnson, D., Lyman, G., Tabbara, I., Kris, M., Grous, J., Picozzi, V., Rausch, G. N. Engl. J. Med. (1991) [Pubmed]
  27. Increase in Candida krusei infection among patients with bone marrow transplantation and neutropenia treated prophylactically with fluconazole. Wingard, J.R., Merz, W.G., Rinaldi, M.G., Johnson, T.R., Karp, J.E., Saral, R. N. Engl. J. Med. (1991) [Pubmed]
  28. Suppressor cell-mediated neutropenia in Felty's syndrome. Abdou, N.I., NaPombejara, C., Balentine, L., Abdou, N.L. J. Clin. Invest. (1978) [Pubmed]
  29. Rheumatoid arthritis associated with expanded populations of granular lymphocytes. Barton, J.C., Prasthofer, E.F., Egan, M.L., Heck, L.W., Koopman, W.J., Grossi, C.E. Ann. Intern. Med. (1986) [Pubmed]
  30. Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme. Aritomi, M., Kunishima, N., Okamoto, T., Kuroki, R., Ota, Y., Morikawa, K. Nature (1999) [Pubmed]
  31. Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene. Hermans, M.H., Antonissen, C., Ward, A.C., Mayen, A.E., Ploemacher, R.E., Touw, I.P. J. Exp. Med. (1999) [Pubmed]
  32. Delineation of Cohen syndrome following a large-scale genotype-phenotype screen. Kolehmainen, J., Wilkinson, R., Lehesjoki, A.E., Chandler, K., Kivitie-Kallio, S., Clayton-Smith, J., Träskelin, A.L., Waris, L., Saarinen, A., Khan, J., Gross-Tsur, V., Traboulsi, E.I., Warburg, M., Fryns, J.P., Norio, R., Black, G.C., Manson, F.D. Am. J. Hum. Genet. (2004) [Pubmed]
  33. Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro. Paquette, R.L., Zhou, J.Y., Yang, Y.C., Clark, S.C., Koeffler, H.P. Blood (1988) [Pubmed]
  34. Human alloantibody anti-Mart interferes with Mac-1-dependent leukocyte adhesion. Sachs, U.J., Chavakis, T., Fung, L., Lohrenz, A., Bux, J., Reil, A., Ruf, A., Santoso, S. Blood (2004) [Pubmed]
  35. Granulocyte colony-stimulating factor in severe chemotherapy-induced afebrile neutropenia. Hartmann, L.C., Tschetter, L.K., Habermann, T.M., Ebbert, L.P., Johnson, P.S., Mailliard, J.A., Levitt, R., Suman, V.J., Witzig, T.E., Wieand, H.S., Miller, L.L., Moertel, C.G. N. Engl. J. Med. (1997) [Pubmed]
  36. Neutropenia and thrombocytopenia in renal allograft recipients treated with trimethoprim-sulfamethoxazole. Bradley, P.P., Warden, G.D., Maxwell, J.G., Rothstein, G. Ann. Intern. Med. (1980) [Pubmed]
  37. Zygomycetes in human disease. Ribes, J.A., Vanover-Sams, C.L., Baker, D.J. Clin. Microbiol. Rev. (2000) [Pubmed]
  38. Neutrophil adhesiveness during prostacyclin and heparin hemodialysis. Spagnuolo, P.J., Bass, S.H., Smith, M.C., Danviriyasup, K., Dunn, M.J. Blood (1982) [Pubmed]
  39. Cyclic neutropenia: amplification of granulocyte oscillations by lithium and long-term suppression of cycling by plasmapheresis. von Schulthess, G.K., Fehr, J., Dahinden, C. Blood (1983) [Pubmed]
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