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Chemical Compound Review:

Chloroquinone 2-chlorocyclohexa-2,5-diene- 1,4-dione

Synonyms: UPCMLD-DP088, SureCN63786, CCRIS 7147, ACMC-20ao0p, NSC-526777, ...

Molinari, A. et al., Tjoeng, M.M. et al.

Molinari, Oliva, Ojeda, Escobar, Gallardo, Miguel del Corral, Castro, Cuevas, San Feliciano,

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High impact information on NSC 526777

From the Diels-Alder adduct between alpha-myrcene and 2-chloro-1,4-benzoquinone, a family of chloro derivatives of prenylnaphthohydroquinone have been synthesised and evaluated for their cytotoxicity against 14 neoplastic cell lines [1].
The relative bioavailability of chloroquinone in Witepsol H15 suppositories can vary between 10 and 53% of the bioavailability of a tablet formulation in adults [2].

References

Synthesis, characterisation and cytotoxicity of chloro derivatives of prenylnaphthohydroquinone. Molinari, A., Oliva, A., Ojeda, C., Escobar, J., Gallardo, C., Miguel del Corral, J.M., Castro, M.A., Cuevas, C., San Feliciano, A. Bioorg. Med. Chem. (2005) [Pubmed]
Comparative bioavailability of rectal and oral formulations of chloroquine. Tjoeng, M.M., Hogeman, P.H., Kapelle, H., De Ridder, M.L., Verhaar, H. Pharmaceutisch weekblad. Scientific edition. (1991) [Pubmed]

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