Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

PubChem3375 1-(2,4- dihydroxyphenyl)ethanone

Synonyms: SureCN26357, CHEMBL243374, AG-K-88693, ACMC-209r36, CHEBI:18414, ...

Yasuda, T. et al., Mutoh, M. et al.

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High impact information on NSC10883

Further examination of the role of the hydroxyl group in the A ring showed that bromination of resacetophenone to give 3,5-dibromo-2,4-dihydroxyacetophenone resulted in a 6.8-fold increase in potency for suppressing COX-2 promoter activity [1].

Analytical, diagnostic and therapeutic context of NSC10883

The urinary metabolites were analyzed by 3D HPLC, and their structures were determined to be 2, 4-dihydroxyacetophenone-5-O-sulfate (P1), resacetophenone-2-O-sulfate (P2), 2-hydroxy-4-methoxyacetophenone-5-O-sulfate (P3), paeonol-2-O-sulfate(P4), resacetophenone (P5), and unchanged paeonol, on the basis of their chemical and spectral data [2].

References

Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationship. Mutoh, M., Takahashi, M., Fukuda, K., Komatsu, H., Enya, T., Matsushima-Hibiya, Y., Mutoh, H., Sugimura, T., Wakabayashi, K. Jpn. J. Cancer Res. (2000) [Pubmed]
Metabolism of paeonol in rats. Yasuda, T., Kon, R., Nakazawa, T., Ohsawa, K. J. Nat. Prod. (1999) [Pubmed]

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