Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Anthranie benzo[d]isoxazole

Synonyms: Indoxazene, indoxazine, Isoindoxazine, benzisoxazole, benzoisoxazole, ...

Jain, M. et al., Matsumoto, K. et al., Liu, X.C. et al.

Liu, Lemma-Gray,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Indoxazene

Microsomal cytochrome p450 and/or p450 reductase appear to be involved in the reductive metabolism of 1,2-benzisoxazole moiety under hypoxic as well as oxic conditions [1].
In this study, we report the catalytic property of BSA on the isomerization of 1,2-benzisoxazole in an organic solvent [2].

Analytical, diagnostic and therapeutic context of Indoxazene

Disposition of 3 - (sulfamoyl[14C]methyl) - 1,2-benzisoxazole ( [14C]AD-810) in rats, dogs and monkeys after oral administration in 20 mg/kg was studied [3].

References

1,2-benzisoxazole phosphorodiamidates as novel anticancer prodrugs requiring bioreductive activation. Jain, M., Kwon, C.H. J. Med. Chem. (2003) [Pubmed]
Biocatalysis of isomerization of 1,2-benzisoxazole by bovine serum albumin in an organic solvent. Liu, X.C., Lemma-Gray, P. Biotechnol. Bioeng. (2001) [Pubmed]
Absorption, distribution and excretion of 3-(sulfamoyl[14C]methyl)-1,2-benziosoxazole (AD-810) in Rats, Dogs and Monkeys and of AD-810 in Men. Matsumoto, K., Miyazaki, H., Fujii, T., Kagemoto, A., Maeda, T., Hashimoto, M. Arzneimittel-Forschung. (1983) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share