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Chemical Compound Review:

PubChem15940 2-phenylquinoline

Synonyms: CHEMBL89786, SureCN44999, SureCN1566083, QC-1123, Bionet2_001089, ...

Fournet, A. et al., Vu, A.T. et al., Blaney, F.E. et al.

Fournet, Ferreira, Rojas De Arias, Torres De Ortiz, Fuentes, Nakayama, Schinini, Hocquemiller, Vu, Cohn, Manas, Harris, Mewshaw,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on AIDS-167239

A stepwise chemical modification from human neurokinin-3 receptor (hNK-3R)-selective antagonists to potent and combined hNK-3R and hNK-2R antagonists using the same 2-phenylquinoline template is described [1].
A new class of estrogen receptor beta (ERbeta) ligands based on the 2-phenylquinoline scaffold was prepared [2].
ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives [2].

Analytical, diagnostic and therapeutic context of AIDS-167239

Other 2-substituted quinolines, 2-n-propylquinoline administered by the oral and intralesional routes, 2-phenylquinoline administered by the oral route, 2-n-pentylquinoline administered by intralesional injection, and two total alkaloidal extracts of G. longiflora administered by the oral route, had intermediate effects [3].

References

Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists. Blaney, F.E., Raveglia, L.F., Artico, M., Cavagnera, S., Dartois, C., Farina, C., Grugni, M., Gagliardi, S., Luttmann, M.A., Martinelli, M., Nadler, G.M., Parini, C., Petrillo, P., Sarau, H.M., Scheideler, M.A., Hay, D.W., Giardina, G.A. J. Med. Chem. (2001) [Pubmed]
ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Vu, A.T., Cohn, S.T., Manas, E.S., Harris, H.A., Mewshaw, R.E. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
In vivo efficacy of oral and intralesional administration of 2-substituted quinolines in experimental treatment of new world cutaneous leishmaniasis caused by Leishmania amazonensis. Fournet, A., Ferreira, M.E., Rojas De Arias, A., Torres De Ortiz, S., Fuentes, S., Nakayama, H., Schinini, A., Hocquemiller, R. Antimicrob. Agents Chemother. (1996) [Pubmed]

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