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Chemical Compound Review

Hesperin     (2S)-5,7-dihydroxy-2-(3- hydroxy-4-methoxy...

Synonyms: Hesperitin, hesperetin, YSO2, Prestwick_908, SPECTRUM310012, ...
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High impact information on TNP00238

  • The caspase-3 inhibitor, Ac-DEVD-FMK, but not the caspase-1 inhibitor, Ac-YVAD-FMK, attenuated HT- and NE-induced cell death [1].
  • Our experiments provide the first evidence to suggest that rutinoside in flavonoids prevents the induction of apoptosis, and that activation of the traditional caspase-3 cascade participates in HT- and NE-induced apoptosis [1].

Analytical, diagnostic and therapeutic context of TNP00238

  • In addition, the rutinoside group in HD and NI was removed by hesperidinase and naringinase, accompanied by the production of HT and NE, respectively, according to HPLC analysis [1].


  1. Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids. Chen, Y.C., Shen, S.C., Lin, H.Y. Biochem. Pharmacol. (2003) [Pubmed]
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