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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

AGN-PC-00BKFN     (3,7-dimethylocta-2,6- dienoxy-hydroxy...

Synonyms: AG-F-34187, AG-J-09476, CTK1C2462, CTK5J8964, AC1L19WK, ...
 
 
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High impact information on Geranyl diphosphate

  • The amino acid sequence (molecular mass approximately 39 kDa) is homologous to polyprenyl-diphosphate synthases from different organisms, showing the seven conserved motifs and the typical hydrophobic profile [1].
  • A kinetic study shows substrate inhibition by isopentenyl-PP at concentrations above 0.7 microM when the concentration of geranyl-PP is 1.0 microM or less as a result of binding by the homoallylic substrate to the allylic region of the active site [2].
 

Associations of Geranyl diphosphate with other chemical compounds

  • We found that analogue 1d displaces approximately the same volume of the active site as does FPP, whereas GPP and analogues 1a-c occupy lesser volumes and 1e occupies a slightly larger volume [3].

References

  1. A Solanesyl-diphosphate Synthase Localizes in Glycosomes of Trypanosoma cruzi. Ferella, M., Montalvetti, A., Rohloff, P., Miranda, K., Fang, J., Reina, S., Kawamukai, M., B??a, J., Nilsson, D., Pravia, C., Katzin, A., Cassera, M.B., Aslund, L., Andersson, B., Docampo, R., Bontempi, E.J. J. Biol. Chem. (2006) [Pubmed]
  2. Prenyltransferase. Kinetic studies of the 1'-4 coupling reaction with avian liver enzyme. Laskovics, F.M., Krafcik, J.M., Poulter, C.D. J. Biol. Chem. (1979) [Pubmed]
  3. Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups. Micali, E., Chehade, K.A., Isaacs, R.J., Andres, D.A., Spielmann, H.P. Biochemistry (2001) [Pubmed]
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