Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AD-41 2,2,2-trifluoro-N- [(2S,3S,4S,6S)-3-hydroxy...

Synonyms: AD41, KST-1A3344, AD 41, LS-94123, NSC283464, ...

Zini, G. et al., Ganapathi, R. et al., Krishan, A. et al.

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High impact information on N-Trifluoroacetyladriamycin

Results from this study indicate that in P388/DOX cells, the calmodulin inhibitor TFP is more effective with DAU than DOX, significantly less effective with ACM, and ineffective with AD32 and N-trifluoroacetyladriamycin [1].
Cells exposed to N-trifluoroacetyladriamycin and carminomycin had higher amounts of intracellular fluorescence (2 to 4 times), and peak values were reached much more rapidly than in cells exposed to ADR [2].
Urinary radioactivity excreted in the 0-24 h interval was only 2.3% of the dose, N-trifluoroacetyldoxorubicin (AD 41), 13-dihydro-N-trifluoroacetyldoxorubicin (AD 92), and doxorubicin being the major urinary metabolites identified [3].

References

Differential effect of the calmodulin inhibitor trifluoperazine on cellular accumulation, retention, and cytotoxicity of anthracyclines in doxorubicin (adriamycin)-resistant P388 mouse leukemia cells. Ganapathi, R., Grabowski, D., Rouse, W., Riegler, F. Cancer Res. (1984) [Pubmed]
Laser flow cytometric studies on the intracellular fluorescence of anthracyclines. Krishan, A., Ganapathi, R. Cancer Res. (1980) [Pubmed]
Radioactive species in rat urines and tissues after [14C] AD 32 administration. Zini, G., Vicario, G.P., Lazzati, M., Arcamone, F. Cancer Chemother. Pharmacol. (1984) [Pubmed]

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