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Chemical Compound Review:

NSC-1127 2-hydroxyethylurea

Synonyms: ACMC-1CNTR, AG-E-52608, ANW-24226, NSC1127, AC1L2KXY, ...

Liao, Y.F. et al., Esler, W.P. et al.

Liao, Wang, Hsu, Lee, Liao, Wu, Cheng, Hu,

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Disease relevance of Monoethylolurea

Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells [1].

High impact information on Monoethylolurea

Our results suggest that (hydroxyethyl)urea peptidomimetics containing unnatural amino acid substitutions could represent a novel class of gamma-secretase inhibitors with enhanced stability, providing the basis for the further development of effective therapeutics for AD and neuroblastomas [1].
Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics [2].

References

Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells. Liao, Y.F., Wang, B.J., Hsu, W.M., Lee, H., Liao, C.Y., Wu, S.Y., Cheng, H.T., Hu, M.K. Mol. Pharmacol. (2007) [Pubmed]
Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics. Esler, W.P., Das, C., Wolfe, M.S. Bioorg. Med. Chem. Lett. (2004) [Pubmed]

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