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Chemical Compound Review:

SureCN2593 3-phenylpropanamide

Synonyms: ACMC-1C2XA, AG-C-24992, SureCN1714311, ANW-14763, NSC-229316, ...

Meuldermans, W. et al., Przegaliński, E. et al.

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High impact information on Phenylpropanamide

Other Phase I pathways were aromatic hydroxylation, N-dealkylation of the piperidine ring from the phenylpropanamide nitrogen, O-demethylation, and amide hydrolysis followed by N-acetylation [1].
Another 5-HT1A receptor antagonist, (S)-WAY 100135 ((S)-N-tert-butyl-3-[4-(2-methoxyphenyl)piperazine-1-yl]-2- phenylpropanamide), was used as a reference drug in functional models [2].

References

Alfentanil pharmacokinetics and metabolism in humans. Meuldermans, W., Van Peer, A., Hendrickx, J., Woestenborghs, R., Lauwers, W., Heykants, J., Vanden Bussche, G., Van Craeyvelt, H., Van der Aa, P. Anesthesiology (1988) [Pubmed]
MP-3022, a new putative antagonist at pre- and postsynaptic 5-HT1A receptors. Przegaliński, E., Filip, M., Bijak, M., Wedzony, K., Budziszewska, B., Tokarski, K., Maćkowiak, M., Fijał, K. Polish journal of pharmacology. (1996) [Pubmed]

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