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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Prunolide     5-pentyloxolan-2-one

Synonyms: apricolin, Aldehyde C-18, CHEMBL191935, SureCN112484, Nonan-4-olide, ...
 
 
 
 
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Disease relevance of gamma-Amyl-gamma-butyrolactone

  • The key step and culmination of the synthesis, responsible for zipping up the spirocyclic core, is a singlet oxygen-orchestrated cascade sequence in which a double photooxygenation of a 1,2-difuryl alkene precursor precedes dehydration and spirocyclization to furnish the intact prunolide core [1].

References

  1. Synthesis of the spirocyclic core of the prunolides using a singlet oxygen-mediated cascade sequence. Sofikiti, N., Tofi, M., Montagnon, T., Vassilikogiannakis, G., Stratakis, M. Org. Lett. (2005) [Pubmed]
 
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