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Chemical Compound Review:

PubChem7517 quinoline-3-carboxylic acid

Synonyms: SureCN28048, CHEMBL275098, ACMC-1BFC6, AG-G-43424, ANW-34949, ...

Segawa, J. et al., Schräder, T. et al., Wentland, M.P. et al., Erickson, E.H. et al.

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High impact information on quinoline-3-carboxylic acid

Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships [1].
Quinoline-3-carboxylic acid (3) was found to have weak oral activity in the rat passive cutaneous (PCA) assay [2].
Pyridine-3,5-dicarboxylic acid and quinoline-3-carboxylic acid were further substrates, but exhibited significantly different activity pH optima [3].

Analytical, diagnostic and therapeutic context of quinoline-3-carboxylic acid

Optically active isomers of 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H- [1,3] thiazeto [3,2-alpha] quinoline-3- carboxylic acid (NM394, 3) were prepared through optical resolution of their racemic intermediate ( +/- )-1 by high-performance liquid chromatography (HPLC) [4].

References

Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships. Wentland, M.P., Bailey, D.M., Cornett, J.B., Dobson, R.A., Powles, R.G., Wagner, R.B. J. Med. Chem. (1984) [Pubmed]
Inhibition of rat passive cutaneous anaphylaxis by 3-(tetrazol-5-yl)quinolines. Erickson, E.H., Hainline, C.F., Lenon, L.S., Matson, C.J., Rice, T.K., Swingle, K.E., Van Winkle, M. J. Med. Chem. (1979) [Pubmed]
A molybdenum-containing dehydrogenase catalyzing an unusual 2-hydroxylation of nicotinic acid. Schräder, T., Thiemer, B., Andreesen, J.R. Appl. Microbiol. Biotechnol. (2002) [Pubmed]
Studies on pyridonecarboxylic acids. IV. Synthesis and antibacterial activity evaluation of S-(-)- and R-(+)-6-fluoro-1-methyl-4-oxo-7- (1-piperazinyl)-4H-[1,3] thiazeto[3,2-a]quinoline-3-carboxylic acids. Segawa, J., Kazuno, K., Matsuoka, M., Amimoto, I., Ozaki, M., Matsuda, M., Tomii, Y., Kitano, M., Kise, M. Chem. Pharm. Bull. (1995) [Pubmed]

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