Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN1610786 7-chloro-N-[2-[4-[2-[(7- chloroquinolin-4...

Synonyms: LS-142109, NSC 129790, WR 3863, BRN 0867697, AC1L33Z2, ...

Deloron, P. et al., Le Bras, J. et al.

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High impact information on WR 3863

In vitro activity of amodiaquine, dichlorquinazine, quinine, mefloquine and halofantrine was good against all isolates (maximum IC50 was 76, 92, 560, less than or equal to 20 and less than or equal to 12 nM, respectively) [1].

Biological context of WR 3863

Very different levels of sensitivity were observed in Brazil and Madagascar. 27 of 28 isolates (including two that were chloroquine-resistant in vivo) had IC50 of less than 50 nM for dichlorquinazine, a 4-aminoquinoline [2].

References

Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs. Deloron, P., Le Bras, J., Ramanamirija, J.A., Coulanges, P. Ann. Trop. Med. Parasitol. (1985) [Pubmed]
Application of an in vitro semi-microtest to the study of drug sensitivity of 66 Plasmodium falciparum isolates from 15 countries. Le Bras, J., Deloron, P., Hartmann, J.F., Coulanges, P., Dourado, H.V., Larouze, B. Trans. R. Soc. Trop. Med. Hyg. (1984) [Pubmed]

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