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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

PNPX     (2S,3R,4S,5R)-2-(4- nitrophenoxy)oxane-3,4...

Synonyms: ARK058, SureCN110451, AG-E-46485, N2132_SIGMA, XYL1-|A-PNP, ...
 
 
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High impact information on p-Nitrophenyl beta-xylopyranoside

  • Based on the expression of Type X collagen, however, PNPX is also a potent inhibitor of chondrocyte differentiation [1].
  • Treatment of secondary cultures of embryonic chick chondrocytes with non-toxic concentrations of the beta-xyloside p-nitrophenyl beta-D-xylopyranoside (PNPX) resulted in dose-dependent inhibition of both proteoglycan and mineral deposition [1].
  • The specific activity and pH and temperature optima for hydrolysis of p-nitrophenyl-beta-D-xylopyranoside (pNPX) were 5.53 U mg-1, 5.5 and 70 degrees C, respectively [2].

References

  1. Inhibition of proteoglycan biosynthesis decreases the calcification of chondrocyte cultures. Hunter, G.K., Weinert, C.A. Connect. Tissue Res. (1996) [Pubmed]
  2. Genetic organization, sequence and biochemical characterization of recombinant beta-xylosidase from Thermoanaerobacterium saccharolyticum strain B6A-RI. Lee, Y.E., Zeikus, J.G. J. Gen. Microbiol. (1993) [Pubmed]
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