Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Ostreasterol (3S,8S,9S,10R,13R,14S,17R)- 10,13-dimethyl...

Synonyms: Chalinasterol, SureCN42185, CHEMBL477971, CHEBI:19812, AC1L3NFY, ...

Choe, S. et al., Choe, S. et al., Du, L. et al.

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High impact information on Chalinasterol

Feeding studies with BR biosynthetic intermediates and analysis of endogenous levels of BR and sterol biosynthetic intermediates indicate that the defective step in dwf7-1 resides before the production of 24-methylenecholesterol in the sterol biosynthetic pathway [1].
The Arabidopsis dwarf1 mutant is defective in the conversion of 24-methylenecholesterol to campesterol in brassinosteroid biosynthesis [2].
Analysis of the endogenous levels of brassinosteroid intermediates showed that 24-methylenecholesterol in dwf1 accumulates to 12 times the level of the wild type, whereas the level of campesterol is greatly diminished, indicating that the defective step is in C-24 reduction [2].

Gene context of Chalinasterol

Arabidopsis DWARF1 (DWF1) is responsible for an early step in brassinosteroid biosynthesis that converts 24-methylenecholesterol to campesterol [3].

References

The Arabidopsis dwf7/ste1 mutant is defective in the delta7 sterol C-5 desaturation step leading to brassinosteroid biosynthesis. Choe, S., Noguchi, T., Fujioka, S., Takatsuto, S., Tissier, C.P., Gregory, B.D., Ross, A.S., Tanaka, A., Yoshida, S., Tax, F.E., Feldmann, K.A. Plant Cell (1999) [Pubmed]
The Arabidopsis dwarf1 mutant is defective in the conversion of 24-methylenecholesterol to campesterol in brassinosteroid biosynthesis. Choe, S., Dilkes, B.P., Gregory, B.D., Ross, A.S., Yuan, H., Noguchi, T., Fujioka, S., Takatsuto, S., Tanaka, A., Yoshida, S., Tax, F.E., Feldmann, K.A. Plant Physiol. (1999) [Pubmed]
Ca2+/calmodulin is critical for brassinosteroid biosynthesis and plant growth. Du, L., Poovaiah, B.W. Nature (2005) [Pubmed]

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