Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL486954 (5R,8S,9S,10S,13S,14S,17S)- 17-ethanoyl-10...

Synonyms: SureCN675417, CPD-5962, AG-D-58369, CHEBI:30154, NSC-82868, ...

Matsunaga, M. et al., Grazzini, E. et al., Ukena, K. et al.

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High impact information on NSC 82868

These effects are highly steroid- and receptor-specific, because binding and signalling functions of the closely related human OTR are not affected by P4 itself but by the P4 metabolite 5beta-dihydroprogesterone [1].
Employing biochemical techniques combined with HPLC and TLC analyses, the conversion of progesterone to 3beta,5beta-tetrahydroprogesterone (3beta,5beta-THP) via 5beta-dihydroprogesterone (5beta-DHP) was found in the brain [2].

Associations of NSC 82868 with other chemical compounds

Biochemical analysis together with HPLC and TLC revealed that only the embryonic brain actively produced 5beta-dihydroprogesterone from progesterone [3].

References

Inhibition of oxytocin receptor function by direct binding of progesterone. Grazzini, E., Guillon, G., Mouillac, B., Zingg, H.H. Nature (1998) [Pubmed]
Identification of 3beta,5beta-tetrahydroprogesterone, a progesterone metabolite, and its stimulatory action on preoptic neurons in the avian brain. Matsunaga, M., Okuhara, K., Ukena, K., Tsutsui, K. Brain Res. (2004) [Pubmed]
Developmental changes in progesterone biosynthesis and metabolism in the quail brain. Ukena, K., Honda, Y., Lea, R.W., Tsutsui, K. Brain Res. (2001) [Pubmed]

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