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Chemical Compound Review

AGN-PC-0070ST     10,13-dimethyl- 2,3,4,5,6,7,8,9,11,12,14,15...

Synonyms: AG-H-63195, Oprea1_360462, CTK5G3550, AC1L96X2, 898285-82-0, ...
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Disease relevance of C00377


Psychiatry related information on C00377


High impact information on C00377

  • Molecular mechanisms of action of steroid/thyroid receptor superfamily members [11].
  • Absorption of NaCl is a rather steady process that is controlled by steroid hormones regulating the expression of epithelial Na(+) channels (ENaC), the Na(+)-K(+)-ATPase, and additional modulating factors such as the serum- and glucocorticoid-regulated kinase SGK [12].
  • The function and physiological regulation of the OT system is strongly steroid dependent [13].
  • The development of selective estrogen receptor modulators has provided a new approach to the prevention of osteoporosis and other major diseases of menopause and has implications for the therapeutic use of other steroid hormones, including androgens [14].
  • They have clarified how both peptide and steroid hormones, including aldosterone and estrogen, regulate ion transport by distal convoluted tubule cells [15].

Chemical compound and disease context of C00377


Biological context of C00377


Anatomical context of C00377


Associations of C00377 with other chemical compounds


Gene context of C00377

  • Biochemical fractionation shows that SRA exists in distinct ribonucleoprotein complexes, one of which contains the nuclear receptor coactivator steroid receptor coactivator 1 [36].
  • Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid levels and responses to half of all oxidatively metabolized drugs [37].
  • SRA is selective for steroid hormone receptors and mediates transactivation via their amino-terminal activation function [36].
  • We propose that BAK1 and BRI1 function together to mediate plant steroid signaling [38].
  • CBP enhances transcriptional activities via histone acetylation and the recruitment of additional co-activators such as SRC (steroid coactivator)-1 (ref. 9). To identify its physiological functions using a loss-of-function mutant, we analyzed CBP-deficient mice [39].

Analytical, diagnostic and therapeutic context of C00377


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  17. Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone. Mendenhall, C.L., Anderson, S., Garcia-Pont, P., Goldberg, S., Kiernan, T., Seeff, L.B., Sorrell, M., Tamburro, C., Weesner, R., Zetterman, R. N. Engl. J. Med. (1984) [Pubmed]
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  24. Androgen-regulated expression of a cloned rat prostatic c3 gene transfected into mouse mammary tumor cells. Page, M.J., Parker, M.G. Cell (1983) [Pubmed]
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  37. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Kuehl, P., Zhang, J., Lin, Y., Lamba, J., Assem, M., Schuetz, J., Watkins, P.B., Daly, A., Wrighton, S.A., Hall, S.D., Maurel, P., Relling, M., Brimer, C., Yasuda, K., Venkataramanan, R., Strom, S., Thummel, K., Boguski, M.S., Schuetz, E. Nat. Genet. (2001) [Pubmed]
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