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Chemical Compound Review

AGN-PC-0070ST     10,13-dimethyl- 2,3,4,5,6,7,8,9,11,12,14,15...

Synonyms: AG-H-63195, Oprea1_360462, CTK5G3550, AC1L96X2, 898285-82-0, ...
 
 
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Disease relevance of C00377

 

Psychiatry related information on C00377

 

High impact information on C00377

  • Molecular mechanisms of action of steroid/thyroid receptor superfamily members [11].
  • Absorption of NaCl is a rather steady process that is controlled by steroid hormones regulating the expression of epithelial Na(+) channels (ENaC), the Na(+)-K(+)-ATPase, and additional modulating factors such as the serum- and glucocorticoid-regulated kinase SGK [12].
  • The function and physiological regulation of the OT system is strongly steroid dependent [13].
  • The development of selective estrogen receptor modulators has provided a new approach to the prevention of osteoporosis and other major diseases of menopause and has implications for the therapeutic use of other steroid hormones, including androgens [14].
  • They have clarified how both peptide and steroid hormones, including aldosterone and estrogen, regulate ion transport by distal convoluted tubule cells [15].
 

Chemical compound and disease context of C00377

 

Biological context of C00377

 

Anatomical context of C00377

 

Associations of C00377 with other chemical compounds

 

Gene context of C00377

  • Biochemical fractionation shows that SRA exists in distinct ribonucleoprotein complexes, one of which contains the nuclear receptor coactivator steroid receptor coactivator 1 [36].
  • Variation in the CYP3A enzymes, which act in drug metabolism, influences circulating steroid levels and responses to half of all oxidatively metabolized drugs [37].
  • SRA is selective for steroid hormone receptors and mediates transactivation via their amino-terminal activation function [36].
  • We propose that BAK1 and BRI1 function together to mediate plant steroid signaling [38].
  • CBP enhances transcriptional activities via histone acetylation and the recruitment of additional co-activators such as SRC (steroid coactivator)-1 (ref. 9). To identify its physiological functions using a loss-of-function mutant, we analyzed CBP-deficient mice [39].
 

Analytical, diagnostic and therapeutic context of C00377

References

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