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Chemical Compound Review

N7764_SIGMA     1-[3,4-dihydroxy-5- (phosphonooxymethyl)oxo...

Synonyms: AC1L1ADE, AC1Q6RZB, AR-1F2420, 321-02-8, nicotinic acid mononucleotide
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Disease relevance of nicotinate ribonucleotide

  • Expression of the gene identified in Escherichia coli yielded a protein with QAPRTase activities that catalyzed the de novo formation of nicotinic acid mononucleotide (NaMN) [1].
  • RESULTS: The crystal structure of QAPRTase from Salmonella typhimurium has been determined with bound QA to 2.8 A resolution, and with bound NAMN to 3.0 A resolution [2].


  1. Involvement of quinolinate phosphoribosyl transferase in promotion of potato growth by a Burkholderia strain. Wang, K., Conn, K., Lazarovits, G. Appl. Environ. Microbiol. (2006) [Pubmed]
  2. A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase. Eads, J.C., Ozturk, D., Wexler, T.B., Grubmeyer, C., Sacchettini, J.C. Structure (1997) [Pubmed]
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