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Chemical Compound Review

Dihydrouridine     1-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: SureCN40762, AG-F-97491, CHEBI:23774, HMDB00497, AC1L3RYN, ...
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Disease relevance of 5,6-Dihydrouridine

  • The crystal structure of an inhibitory complex formed between Escherichia coli cytidine deaminase and the transition-state analog 3,4-dihydrouridine indicates the presence of a short H-bond between Glu-104 and the inhibitor [1].

High impact information on 5,6-Dihydrouridine

  • The entropic shortcomings of 3,4-dihydrouridine, in capturing all of the free energy involved in binding the actual transition state, may arise from its inability to displace a water molecule that occupies the binding site normally occupied by product ammonia [2].

Associations of 5,6-Dihydrouridine with other chemical compounds


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